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Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6.
J Med Chem. 2023 Oct 12;66(19):13821-13837. doi: 10.1021/acs.jmedchem.3c01345. Epub 2023 Oct 2.
J Med Chem. 2023.
PMID: 37782298
Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia.
Reßing N, Schliehe-Diecks J, Watson PR, Sönnichsen M, Cragin AD, Schöler A, Yang J, Schäker-Hübner L, Borkhardt A, Christianson DW, Bhatia S, Hansen FK.
Reßing N, et al. Among authors: cragin ad.
J Med Chem. 2022 Nov 24;65(22):15457-15472. doi: 10.1021/acs.jmedchem.2c01418. Epub 2022 Nov 9.
J Med Chem. 2022.
PMID: 36351184
Free PMC article.
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Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6.
Watson PR, Bai P, Wang C, Cragin AD, Hooker JM, Christianson DW.
Watson PR, et al. Among authors: cragin ad.
Biochemistry. 2022 Sep 20;61(18):1945-1954. doi: 10.1021/acs.biochem.2c00332. Epub 2022 Sep 8.
Biochemistry. 2022.
PMID: 36073962
Free PMC article.
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