Stephen AG - Search Results

1

RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation.

Spencer-Smith R, Terrell EM, Insinna C, Agamasu C, Wagner ME, Ritt DA, Stauffer J, Stephen AG, Morrison DK. Spencer-Smith R, et al. Among authors: stephen ag. Mol Cell. 2022 Nov 17;82(22):4262-4276.e5. doi: 10.1016/j.molcel.2022.10.016. Epub 2022 Nov 7. Mol Cell. 2022. PMID: 36347258 Free PMC article.

2

Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane.

Shrestha R, Carpenter TS, Van QN, Agamasu C, Tonelli M, Aydin F, Chen D, Gulten G, Glosli JN, López CA, Oppelstrup T, Neale C, Gnanakaran S, Gillette WK, Ingólfsson HI, Lightstone FC, Stephen AG, Streitz FH, Nissley DV, Turbyville TJ. Shrestha R, et al. Among authors: stephen ag. Commun Biol. 2024 Feb 28;7(1):242. doi: 10.1038/s42003-024-05916-0. Commun Biol. 2024. PMID: 38418613 Free PMC article.

3

Progress in Targeting KRAS Directly.

Nissley DV, Stephen AG, Yi M, McCormick F. Nissley DV, et al. Among authors: stephen ag. Methods Mol Biol. 2024;2797:1-12. doi: 10.1007/978-1-0716-3822-4_1. Methods Mol Biol. 2024. PMID: 38570448

4

Author Correction: Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane.

Shrestha R, Carpenter TS, Van QN, Agamasu C, Tonelli M, Aydin F, Chen D, Gulten G, Glosli JN, López CA, Oppelstrup T, Neale C, Gnanakaran S, Gillette WK, Ingólfsson HI, Lightstone FC, Stephen AG, Streitz FH, Nissley DV, Turbyville TJ. Shrestha R, et al. Among authors: stephen ag. Commun Biol. 2024 Apr 11;7(1):445. doi: 10.1038/s42003-024-06061-4. Commun Biol. 2024. PMID: 38605143 Free PMC article. No abstract available.

5

Measurement of KRAS-GTPase Activity.

Rabara D, Stephen AG. Rabara D, et al. Among authors: stephen ag. Methods Mol Biol. 2024;2797:91-102. doi: 10.1007/978-1-0716-3822-4_7. Methods Mol Biol. 2024. PMID: 38570454

6

Affinity Measurement of Non-covalent Interactions of the Covalent KRAS G12C GDP Inhibitor MRTX849 to RAS Isoforms Using Surface Plasmon Resonance.

Alexander P, Stephen AG. Alexander P, et al. Among authors: stephen ag. Methods Mol Biol. 2024;2797:103-114. doi: 10.1007/978-1-0716-3822-4_8. Methods Mol Biol. 2024. PMID: 38570455

7

GAP positions catalytic H-Ras residue Q61 for GTP hydrolysis in molecular dynamics simulations, complicating chemical rescue of Ras deactivation.

Patel LA, Waybright TJ, Stephen AG, Neale C. Patel LA, et al. Among authors: stephen ag. Comput Biol Chem. 2023 Jun;104:107835. doi: 10.1016/j.compbiolchem.2023.107835. Epub 2023 Mar 1. Comput Biol Chem. 2023. PMID: 36893567

8

Revealing KRas4b topology on the membrane surface.

Shree S, McLean MA, Stephen AG, Sligar SG. Shree S, et al. Among authors: stephen ag. Biochem Biophys Res Commun. 2023 Oct 20;678:122-127. doi: 10.1016/j.bbrc.2023.08.035. Epub 2023 Aug 21. Biochem Biophys Res Commun. 2023. PMID: 37633182

9

KRAS4b:RAF-1 Homogenous Time-Resolved Fluorescence Resonance Energy Transfer Assay for Drug Discovery.

Larsen EK, Abreu-Blanco M, Rabara D, Stephen AG. Larsen EK, et al. Among authors: stephen ag. Methods Mol Biol. 2024;2797:159-175. doi: 10.1007/978-1-0716-3822-4_12. Methods Mol Biol. 2024. PMID: 38570459

10

Nucleotide Exchange on RAS Proteins Using Hydrolysable and Non-hydrolysable Nucleotides.

Waybright T, Stephen AG. Waybright T, et al. Among authors: stephen ag. Methods Mol Biol. 2024;2797:35-46. doi: 10.1007/978-1-0716-3822-4_4. Methods Mol Biol. 2024. PMID: 38570451

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