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Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions.
Sakai K, Sugano-Nakamura N, Mihara E, Rojas-Chaverra NM, Watanabe S, Sato H, Imamura R, Voon DC, Sakai I, Yamasaki C, Tateno C, Shibata M, Suga H, Takagi J, Matsumoto K. Sakai K, et al. Among authors: tateno c. Nat Biomed Eng. 2023 Feb;7(2):164-176. doi: 10.1038/s41551-022-00955-6. Epub 2022 Nov 7. Nat Biomed Eng. 2023. PMID: 36344661 Free PMC article.
Molecular insights of a CBP/β-catenin-signaling inhibitor on nonalcoholic steatohepatitis-induced liver fibrosis and disorder.
Yamaji K, Iwabuchi S, Tokunaga Y, Hashimoto S, Yamane D, Toyama S, Kono R, Kitab B, Tsukiyama-Kohara K, Osawa Y, Hayashi Y, Hishima T, Tateno C, Kimura K, Okanoue T, Kohara M. Yamaji K, et al. Among authors: tateno c. Biomed Pharmacother. 2023 Oct;166:115379. doi: 10.1016/j.biopha.2023.115379. Epub 2023 Aug 28. Biomed Pharmacother. 2023. PMID: 37647690 Free article.
Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics.
Hailegiorgis A, Ishida Y, Collier N, Imamura M, Shi Z, Reinharz V, Tsuge M, Barash D, Hiraga N, Yokomichi H, Tateno C, Ozik J, Uprichard SL, Chayama K, Dahari H. Hailegiorgis A, et al. Among authors: tateno c. PLoS Comput Biol. 2023 Aug 3;19(8):e1011309. doi: 10.1371/journal.pcbi.1011309. eCollection 2023 Aug. PLoS Comput Biol. 2023. PMID: 37535676 Free PMC article.
HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice.
Uchida T, Imamura M, Hayes CN, Suehiro Y, Teraoka Y, Ohya K, Aikata H, Abe-Chayama H, Ishida Y, Tateno C, Hara Y, Hino K, Okamoto T, Matsuura Y, Aizaki H, Wake K, Kohara M, Liang TJ, Oka S, Chayama K. Uchida T, et al. Among authors: tateno c. Hepatology. 2023 Sep 1;78(3):929-942. doi: 10.1097/HEP.0000000000000335. Epub 2023 Mar 13. Hepatology. 2023. PMID: 36896966
167 results