Suga H - Search Results

1

Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions.

Sakai K, Sugano-Nakamura N, Mihara E, Rojas-Chaverra NM, Watanabe S, Sato H, Imamura R, Voon DC, Sakai I, Yamasaki C, Tateno C, Shibata M, Suga H, Takagi J, Matsumoto K. Sakai K, et al. Among authors: suga h. Nat Biomed Eng. 2023 Feb;7(2):164-176. doi: 10.1038/s41551-022-00955-6. Epub 2022 Nov 7. Nat Biomed Eng. 2023. PMID: 36344661 Free PMC article.

2

Artificial human Met agonists based on macrocycle scaffolds.

Ito K, Sakai K, Suzuki Y, Ozawa N, Hatta T, Natsume T, Matsumoto K, Suga H. Ito K, et al. Among authors: suga h. Nat Commun. 2015 Mar 11;6:6373. doi: 10.1038/ncomms7373. Nat Commun. 2015. PMID: 25758345 Free PMC article.

3

Allosteric Inhibition of a Semaphorin 4D Receptor Plexin B1 by a High-Affinity Macrocyclic Peptide.

Matsunaga Y, Bashiruddin NK, Kitago Y, Takagi J, Suga H. Matsunaga Y, et al. Among authors: suga h. Cell Chem Biol. 2016 Nov 17;23(11):1341-1350. doi: 10.1016/j.chembiol.2016.09.015. Epub 2016 Oct 27. Cell Chem Biol. 2016. PMID: 27984026 Free article.

4

Facile Synthesis of Dimeric Thioether-Macrocyclic Peptides with Antibody-like Affinity against Plexin-B1.

Bashiruddin NK, Matsunaga Y, Nagano M, Takagi J, Suga H. Bashiruddin NK, et al. Among authors: suga h. Bioconjug Chem. 2018 Jun 20;29(6):1847-1851. doi: 10.1021/acs.bioconjchem.8b00219. Epub 2018 May 21. Bioconjug Chem. 2018. PMID: 29714478

5

MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner.

Miao W, Sakai K, Imamura R, Ito K, Suga H, Sakuma T, Yamamoto T, Matsumoto K. Miao W, et al. Among authors: suga h. Int J Mol Sci. 2018 Oct 12;19(10):3141. doi: 10.3390/ijms19103141. Int J Mol Sci. 2018. PMID: 30322054 Free PMC article.

6

Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist.

Miao W, Sakai K, Ozawa N, Nishiuchi T, Suzuki Y, Ito K, Morioka T, Umitsu M, Takagi J, Suga H, Matsumoto K. Miao W, et al. Among authors: suga h. Sci Rep. 2018 Nov 7;8(1):16492. doi: 10.1038/s41598-018-34835-4. Sci Rep. 2018. PMID: 30405161 Free PMC article.

7

Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor.

Sakai K, Passioura T, Sato H, Ito K, Furuhashi H, Umitsu M, Takagi J, Kato Y, Mukai H, Warashina S, Zouda M, Watanabe Y, Yano S, Shibata M, Suga H, Matsumoto K. Sakai K, et al. Among authors: suga h. Nat Chem Biol. 2019 Jun;15(6):598-606. doi: 10.1038/s41589-019-0285-7. Epub 2019 May 17. Nat Chem Biol. 2019. PMID: 31101918

8

Cyclic Peptide-Based Biologics Regulating HGF-MET.

Sato H, Imamura R, Suga H, Matsumoto K, Sakai K. Sato H, et al. Among authors: suga h. Int J Mol Sci. 2020 Oct 27;21(21):7977. doi: 10.3390/ijms21217977. Int J Mol Sci. 2020. PMID: 33121208 Free PMC article. Review.

9

Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation.

Bashiruddin NK, Hayashi M, Nagano M, Wu Y, Matsunaga Y, Takagi J, Nakashima T, Suga H. Bashiruddin NK, et al. Among authors: suga h. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31070-31077. doi: 10.1073/pnas.2012266117. Epub 2020 Nov 23. Proc Natl Acad Sci U S A. 2020. PMID: 33229551 Free PMC article.

10

Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins.

Mihara E, Watanabe S, Bashiruddin NK, Nakamura N, Matoba K, Sano Y, Maini R, Yin Y, Sakai K, Arimori T, Matsumoto K, Suga H, Takagi J. Mihara E, et al. Among authors: suga h. Nat Commun. 2021 Mar 9;12(1):1543. doi: 10.1038/s41467-021-21875-0. Nat Commun. 2021. PMID: 33750839 Free PMC article.

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