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Discontinuation versus continuation of hypertonic saline or dornase alfa in modulator treated people with cystic fibrosis (SIMPLIFY): results from two parallel, multicentre, open-label, randomised, controlled, non-inferiority trials.
Mayer-Hamblett N, Ratjen F, Russell R, Donaldson SH, Riekert KA, Sawicki GS, Odem-Davis K, Young JK, Rosenbluth D, Taylor-Cousar JL, Goss CH, Retsch-Bogart G, Clancy JP, Genatossio A, O'Sullivan BP, Berlinski A, Millard SL, Omlor G, Wyatt CA, Moffett K, Nichols DP, Gifford AH; SIMPLIFY Study Group. Mayer-Hamblett N, et al. Among authors: nichols dp. Lancet Respir Med. 2023 Apr;11(4):329-340. doi: 10.1016/S2213-2600(22)00434-9. Epub 2022 Nov 4. Lancet Respir Med. 2023. PMID: 36343646 Free PMC article. Clinical Trial.
Effects of gender and age at diagnosis on disease progression in long-term survivors of cystic fibrosis.
Nick JA, Chacon CS, Brayshaw SJ, Jones MC, Barboa CM, St Clair CG, Young RL, Nichols DP, Janssen JS, Huitt GA, Iseman MD, Daley CL, Taylor-Cousar JL, Accurso FJ, Saavedra MT, Sontag MK. Nick JA, et al. Among authors: nichols dp. Am J Respir Crit Care Med. 2010 Sep 1;182(5):614-26. doi: 10.1164/rccm.201001-0092OC. Epub 2010 May 6. Am J Respir Crit Care Med. 2010. PMID: 20448091 Free PMC article.
Mycobacterium abscessus induces a limited pattern of neutrophil activation that promotes pathogen survival.
Malcolm KC, Nichols EM, Caceres SM, Kret JE, Martiniano SL, Sagel SD, Chan ED, Caverly L, Solomon GM, Reynolds P, Bratton DL, Taylor-Cousar JL, Nichols DP, Saavedra MT, Nick JA. Malcolm KC, et al. Among authors: nichols dp, nichols em. PLoS One. 2013;8(2):e57402. doi: 10.1371/journal.pone.0057402. Epub 2013 Feb 25. PLoS One. 2013. PMID: 23451220 Free PMC article.
Effects of azithromycin in Pseudomonas aeruginosa burn wound infection.
Nichols DP, Caceres S, Caverly L, Fratelli C, Kim SH, Malcolm K, Poch KR, Saavedra M, Solomon G, Taylor-Cousar J, Moskowitz S, Nick JA. Nichols DP, et al. J Surg Res. 2013 Aug;183(2):767-76. doi: 10.1016/j.jss.2013.02.003. Epub 2013 Feb 24. J Surg Res. 2013. PMID: 23478086 Free PMC article.
Enhanced in vitro formation and antibiotic resistance of nonattached Pseudomonas aeruginosa aggregates through incorporation of neutrophil products.
Caceres SM, Malcolm KC, Taylor-Cousar JL, Nichols DP, Saavedra MT, Bratton DL, Moskowitz SM, Burns JL, Nick JA. Caceres SM, et al. Among authors: nichols dp. Antimicrob Agents Chemother. 2014 Nov;58(11):6851-60. doi: 10.1128/AAC.03514-14. Epub 2014 Sep 2. Antimicrob Agents Chemother. 2014. PMID: 25182651 Free PMC article.
Long-term treatment with oral N-acetylcysteine: affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial.
Conrad C, Lymp J, Thompson V, Dunn C, Davies Z, Chatfield B, Nichols D, Clancy J, Vender R, Egan ME, Quittell L, Michelson P, Antony V, Spahr J, Rubenstein RC, Moss RB, Herzenberg LA, Goss CH, Tirouvanziam R. Conrad C, et al. J Cyst Fibros. 2015 Mar;14(2):219-27. doi: 10.1016/j.jcf.2014.08.008. Epub 2014 Sep 13. J Cyst Fibros. 2015. PMID: 25228446 Free article. Clinical Trial.
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