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Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever.
Mangan MSJ, Gorki F, Krause K, Heinz A, Pankow A, Ebert T, Jahn D, Hiller K, Hornung V, Maurer M, Schmidt FI, Gerhard R, Latz E. Mangan MSJ, et al. Among authors: gorki f. PLoS Biol. 2022 Nov 7;20(11):e3001351. doi: 10.1371/journal.pbio.3001351. eCollection 2022 Nov. PLoS Biol. 2022. PMID: 36342970 Free PMC article.
d-2-Hydroxyglutarate is an anti-inflammatory immunometabolite that accumulates in macrophages after TLR4 activation.
de Goede KE, Harber KJ, Gorki FS, Verberk SGS, Groh LA, Keuning ED, Struys EA, van Weeghel M, Haschemi A, de Winther MPJ, van Dierendonck XAMH, Van den Bossche J. de Goede KE, et al. Among authors: gorki fs. Biochim Biophys Acta Mol Basis Dis. 2022 Sep 1;1868(9):166427. doi: 10.1016/j.bbadis.2022.166427. Epub 2022 May 6. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35526742 Free article.
An integrated toolbox to profile macrophage immunometabolism.
Verberk SGS, de Goede KE, Gorki FS, van Dierendonck XAMH, Argüello RJ, Van den Bossche J. Verberk SGS, et al. Among authors: gorki fs. Cell Rep Methods. 2022 Mar 28;2(4):100192. doi: 10.1016/j.crmeth.2022.100192. eCollection 2022 Apr 25. Cell Rep Methods. 2022. PMID: 35497494 Free PMC article.
α2-3 Sialic acid binding and uptake by human monocyte-derived dendritic cells alters metabolism and cytokine release and initiates tolerizing T cell programming.
Lübbers J, Eveline Li RJ, Gorki FS, Bruijns SCM, Gallagher A, Kalay H, Ambrosini M, Molenaar D, Van den Bossche J, van Vliet SJ, van Kooyk Y. Lübbers J, et al. Among authors: gorki fs. Immunother Adv. 2021 Jun 9;1(1):ltab012. doi: 10.1093/immadv/ltab012. eCollection 2021 Jan. Immunother Adv. 2021. PMID: 35919745 Free PMC article.