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Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity.
Kaplan AL, Confair DN, Kim K, Barros-Álvarez X, Rodriguiz RM, Yang Y, Kweon OS, Che T, McCorvy JD, Kamber DN, Phelan JP, Martins LC, Pogorelov VM, DiBerto JF, Slocum ST, Huang XP, Kumar JM, Robertson MJ, Panova O, Seven AB, Wetsel AQ, Wetsel WC, Irwin JJ, Skiniotis G, Shoichet BK, Roth BL, Ellman JA. Kaplan AL, et al. Among authors: kamber dn. Nature. 2022 Oct;610(7932):582-591. doi: 10.1038/s41586-022-05258-z. Epub 2022 Sep 28. Nature. 2022. PMID: 36171289 Free PMC article.
Isomeric triazines exhibit unique profiles of bioorthogonal reactivity.
Kamber DN, Nguyen SS, Liu F, Briggs JS, Shih HW, Row RD, Long ZG, Houk KN, Liang Y, Prescher JA. Kamber DN, et al. Chem Sci. 2019 Aug 21;10(39):9109-9114. doi: 10.1039/c9sc01427f. eCollection 2019 Oct 21. Chem Sci. 2019. PMID: 31908754 Free PMC article.
1,2,4-Triazines Are Versatile Bioorthogonal Reagents.
Kamber DN, Liang Y, Blizzard RJ, Liu F, Mehl RA, Houk KN, Prescher JA. Kamber DN, et al. J Am Chem Soc. 2015 Jul 8;137(26):8388-91. doi: 10.1021/jacs.5b05100. Epub 2015 Jun 25. J Am Chem Soc. 2015. PMID: 26084312
16 results