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In vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance.
Leukemia. 2022 Dec;36(12):2863-2874. doi: 10.1038/s41375-022-01726-7. Epub 2022 Nov 4.
Leukemia. 2022.
PMID: 36333584
Free PMC article.
Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL.
Liu WH, Mrozek-Gorska P, Wirth AK, Herold T, Schwarzkopf L, Pich D, Völse K, Melo-Narváez MC, Carlet M, Hammerschmidt W, Jeremias I.
Liu WH, et al. Among authors: wirth ak.
Biomark Res. 2020 Sep 16;8:46. doi: 10.1186/s40364-020-00226-z. eCollection 2020.
Biomark Res. 2020.
PMID: 32944247
Free PMC article.
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Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo.
Bahrami E, Schmid JP, Jurinovic V, Becker M, Wirth AK, Ludwig R, Kreissig S, Duque Angel TV, Amend D, Hunt K, Öllinger R, Rad R, Frenz JM, Solovey M, Ziemann F, Mann M, Vick B, Wichmann C, Herold T, Jayavelu AK, Jeremias I.
Bahrami E, et al. Among authors: wirth ak.
Mol Cancer. 2023 Jul 8;22(1):107. doi: 10.1186/s12943-023-01803-0.
Mol Cancer. 2023.
PMID: 37422628
Free PMC article.
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A Dynamic rRNA Ribomethylome Drives Stemness in Acute Myeloid Leukemia.
Zhou F, Aroua N, Liu Y, Rohde C, Cheng J, Wirth AK, Fijalkowska D, Göllner S, Lotze M, Yun H, Yu X, Pabst C, Sauer T, Oellerich T, Serve H, Röllig C, Bornhäuser M, Thiede C, Baldus C, Frye M, Raffel S, Krijgsveld J, Jeremias I, Beckmann R, Trumpp A, Müller-Tidow C.
Zhou F, et al. Among authors: wirth ak.
Cancer Discov. 2023 Feb 6;13(2):332-347. doi: 10.1158/2159-8290.CD-22-0210.
Cancer Discov. 2023.
PMID: 36259929
Free PMC article.
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Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis.
Fan Z, Wirth AK, Chen D, Wruck CJ, Rauh M, Buchfelder M, Savaskan N.
Fan Z, et al. Among authors: wirth ak.
Oncogenesis. 2017 Aug 14;6(8):e371. doi: 10.1038/oncsis.2017.65.
Oncogenesis. 2017.
PMID: 28805788
Free PMC article.
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