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The Pregnane X Receptor and Indole-3-Propionic Acid Shape the Intestinal Mesenchyme to Restrain Inflammation and Fibrosis.
Cell Mol Gastroenterol Hepatol. 2023;15(3):765-795. doi: 10.1016/j.jcmgh.2022.10.014. Epub 2022 Oct 26.
Cell Mol Gastroenterol Hepatol. 2023.
PMID: 36309199
Free PMC article.
The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation.
Pulakazhi Venu VK, Saifeddine M, Mihara K, Tsai YC, Nieves K, Alston L, Mani S, McCoy KD, Hollenberg MD, Hirota SA.
Pulakazhi Venu VK, et al.
Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E350-E361. doi: 10.1152/ajpendo.00572.2018. Epub 2019 Jun 18.
Am J Physiol Endocrinol Metab. 2019.
PMID: 31211619
Free PMC article.
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The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins.
Erickson SL, Alston L, Nieves K, Chang TKH, Mani S, Flannigan KL, Hirota SA.
Erickson SL, et al.
FASEB J. 2020 Feb;34(2):2198-2212. doi: 10.1096/fj.201902083RR. Epub 2019 Dec 17.
FASEB J. 2020.
PMID: 31907988
Free PMC article.
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Xenobiotic receptors and the regulation of intestinal homeostasis: harnessing the chemical output of the intestinal microbiota.
Nieves KM, Hirota SA, Flannigan KL.
Nieves KM, et al.
Am J Physiol Gastrointest Liver Physiol. 2022 Feb 1;322(2):G268-G281. doi: 10.1152/ajpgi.00160.2021. Epub 2021 Dec 23.
Am J Physiol Gastrointest Liver Physiol. 2022.
PMID: 34941453
Free article.
Review.
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Colitis-associated microbiota drives changes in behaviour in male mice in the absence of inflammation.
Vicentini FA, Szamosi JC, Rossi L, Griffin L, Nieves K, Bihan D, Lewis IA, Pittman QJ, Swain MG, Surette MG, Hirota SA, Sharkey KA.
Vicentini FA, et al.
Brain Behav Immun. 2022 May;102:266-278. doi: 10.1016/j.bbi.2022.03.001. Epub 2022 Mar 5.
Brain Behav Immun. 2022.
PMID: 35259427
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