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The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction.
Hansen A, Alston L, Tulk SE, Schenck LP, Grassie ME, Alhassan BF, Veermalla AT, Al-Bashir S, Gendron FP, Altier C, MacDonald JA, Beck PL, Hirota SA. Hansen A, et al. Among authors: hirota sa. PLoS One. 2013 Nov 22;8(11):e81491. doi: 10.1371/journal.pone.0081491. eCollection 2013. PLoS One. 2013. PMID: 24278446 Free PMC article.
Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation.
Garg A, Zhao A, Erickson SL, Mukherjee S, Lau AJ, Alston L, Chang TK, Mani S, Hirota SA. Garg A, et al. Among authors: hirota sa. J Pharmacol Exp Ther. 2016 Oct;359(1):91-101. doi: 10.1124/jpet.116.234096. Epub 2016 Jul 20. J Pharmacol Exp Ther. 2016. PMID: 27440420 Free PMC article.
IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria.
Flannigan KL, Ngo VL, Geem D, Harusato A, Hirota SA, Parkos CA, Lukacs NW, Nusrat A, Gaboriau-Routhiau V, Cerf-Bensussan N, Gewirtz AT, Denning TL. Flannigan KL, et al. Among authors: hirota sa. Mucosal Immunol. 2017 May;10(3):673-684. doi: 10.1038/mi.2016.80. Epub 2016 Sep 14. Mucosal Immunol. 2017. PMID: 27624780 Free PMC article.
Constitutive androstane receptor regulates the intestinal mucosal response to injury.
Hudson GM, Flannigan KL, Erickson SL, Vicentini FA, Zamponi A, Hirota CL, Alston L, Altier C, Ghosh S, Rioux KP, Mani S, Chang TK, Hirota SA. Hudson GM, et al. Among authors: hirota cl, hirota sa. Br J Pharmacol. 2017 Jun;174(12):1857-1871. doi: 10.1111/bph.13787. Epub 2017 Apr 19. Br J Pharmacol. 2017. PMID: 28320072 Free PMC article.
Changes in Composition of the Gut Bacterial Microbiome after Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection in a Pediatric Heart Transplant Patient.
Flannigan KL, Rajbar T, Moffat A, McKenzie LS, Dicke F, Rioux K, Workentine ML, Louie TJ, Hirota SA, Greenway SC. Flannigan KL, et al. Among authors: hirota sa. Front Cardiovasc Med. 2017 Apr 4;4:17. doi: 10.3389/fcvm.2017.00017. eCollection 2017. Front Cardiovasc Med. 2017. PMID: 28421185 Free PMC article.
A simple, cost-effective method for generating murine colonic 3D enteroids and 2D monolayers for studies of primary epithelial cell function.
Fernando EH, Dicay M, Stahl M, Gordon MH, Vegso A, Baggio C, Alston L, Lopes F, Baker K, Hirota S, McKay DM, Vallance B, MacNaughton WK. Fernando EH, et al. Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5):G467-G475. doi: 10.1152/ajpgi.00152.2017. Epub 2017 Jul 27. Am J Physiol Gastrointest Liver Physiol. 2017. PMID: 28751424 Free article.
61 results