Alston LA - Search Results

1

The Pregnane X Receptor and Indole-3-Propionic Acid Shape the Intestinal Mesenchyme to Restrain Inflammation and Fibrosis.

Flannigan KL, Nieves KM, Szczepanski HE, Serra A, Lee JW, Alston LA, Ramay H, Mani S, Hirota SA. Flannigan KL, et al. Among authors: alston la. Cell Mol Gastroenterol Hepatol. 2023;15(3):765-795. doi: 10.1016/j.jcmgh.2022.10.014. Epub 2022 Oct 26. Cell Mol Gastroenterol Hepatol. 2023. PMID: 36309199 Free PMC article.

2

The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins.

Erickson SL, Alston L, Nieves K, Chang TKH, Mani S, Flannigan KL, Hirota SA. Erickson SL, et al. FASEB J. 2020 Feb;34(2):2198-2212. doi: 10.1096/fj.201902083RR. Epub 2019 Dec 17. FASEB J. 2020. PMID: 31907988 Free PMC article.

3

Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis.

Terc J, Hansen A, Alston L, Hirota SA. Terc J, et al. Eur J Pharm Sci. 2014 May 13;55:12-9. doi: 10.1016/j.ejps.2014.01.007. Epub 2014 Jan 29. Eur J Pharm Sci. 2014. PMID: 24486481

4

Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation.

Garg A, Zhao A, Erickson SL, Mukherjee S, Lau AJ, Alston L, Chang TK, Mani S, Hirota SA. Garg A, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):91-101. doi: 10.1124/jpet.116.234096. Epub 2016 Jul 20. J Pharmacol Exp Ther. 2016. PMID: 27440420 Free PMC article.

5

Constitutive androstane receptor regulates the intestinal mucosal response to injury.

Hudson GM, Flannigan KL, Erickson SL, Vicentini FA, Zamponi A, Hirota CL, Alston L, Altier C, Ghosh S, Rioux KP, Mani S, Chang TK, Hirota SA. Hudson GM, et al. Br J Pharmacol. 2017 Jun;174(12):1857-1871. doi: 10.1111/bph.13787. Epub 2017 Apr 19. Br J Pharmacol. 2017. PMID: 28320072 Free PMC article.

6

Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation.

Hudson G, Flannigan KL, Venu VKP, Alston L, Sandall CF, MacDonald JA, Muruve DA, Chang TKH, Mani S, Hirota SA. Hudson G, et al. J Pharmacol Exp Ther. 2019 Jul;370(1):44-53. doi: 10.1124/jpet.118.255679. Epub 2019 Apr 19. J Pharmacol Exp Ther. 2019. PMID: 31004077 Free PMC article.

7

The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation.

Pulakazhi Venu VK, Saifeddine M, Mihara K, Tsai YC, Nieves K, Alston L, Mani S, McCoy KD, Hollenberg MD, Hirota SA. Pulakazhi Venu VK, et al. Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E350-E361. doi: 10.1152/ajpendo.00572.2018. Epub 2019 Jun 18. Am J Physiol Endocrinol Metab. 2019. PMID: 31211619 Free PMC article.

8

Nr4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts.

Pulakazhi Venu VK, Alston L, Iftinca M, Tsai YC, Stephens M, Warriyar K V V, Rehal S, Hudson G, Szczepanski H, von der Weid PY, Altier C, Hirota SA. Pulakazhi Venu VK, et al. Am J Physiol Gastrointest Liver Physiol. 2021 Sep 1;321(3):G280-G297. doi: 10.1152/ajpgi.00338.2019. Epub 2021 Jul 21. Am J Physiol Gastrointest Liver Physiol. 2021. PMID: 34288735 Free article.

9

NR4A1 modulates intestinal smooth muscle cell phenotype and dampens inflammation-associated intestinal remodeling.

Szczepanski HE, Flannigan KL, Mainoli B, Alston L, Baruta GM, Lee JW, Venu VKP, Shearer J, Dufour A, Hirota SA. Szczepanski HE, et al. FASEB J. 2022 Nov;36(11):e22609. doi: 10.1096/fj.202101817RR. FASEB J. 2022. PMID: 36250380

10

An intact microbiota is required for the gastrointestinal toxicity of the immunosuppressant mycophenolate mofetil.

Flannigan KL, Taylor MR, Pereira SK, Rodriguez-Arguello J, Moffat AW, Alston L, Wang X, Poon KK, Beck PL, Rioux KP, Jonnalagadda M, Chelikani PK, Galipeau HJ, Lewis IA, Workentine ML, Greenway SC, Hirota SA. Flannigan KL, et al. J Heart Lung Transplant. 2018 Sep;37(9):1047-1059. doi: 10.1016/j.healun.2018.05.002. Epub 2018 May 23. J Heart Lung Transplant. 2018. PMID: 30173823

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