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Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping.
Břehová P, Řezníčková E, Škach K, Jorda R, Dejmek M, Vojáčková V, Šála M, Kovalová M, Dračínský M, Dolníková A, Strmeň T, Kinnertová M, Chalupský K, Dvořáková A, Gucký T, Mertlíková Kaiserová H, Klener P, Nencka R, Kryštof V. Břehová P, et al. Among authors: gucky t. J Med Chem. 2023 Aug 24;66(16):11133-11157. doi: 10.1021/acs.jmedchem.3c00575. Epub 2023 Aug 3. J Med Chem. 2023. PMID: 37535845 Free PMC article.
In vitro and in silico studies of interaction of synthetic 2,6,9-trisubstituted purine kinase inhibitors BPA-302, BP-21 and BP-117 with liver drug-metabolizing cytochromes P450.
Špičáková A, Kraus P, Gucký T, Kryštof V, Strnad M, Bazgier V, Otyepka M, Kubíčková V, Poruba M, Rácová Z, Zapletalová I, Anzenbacher P. Špičáková A, et al. Among authors: gucky t. Physiol Res. 2020 Dec 31;69(Suppl 4):S627-S636. doi: 10.33549/physiolres.934611. Physiol Res. 2020. PMID: 33646005 Free PMC article.
28 results