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Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome.
Fulton SL, Wenderski W, Lepack AE, Eagle AL, Fanutza T, Bastle RM, Ramakrishnan A, Hays EC, Neal A, Bendl J, Farrelly LA, Al-Kachak A, Lyu Y, Cetin B, Chan JC, Tran TN, Neve RL, Roper RJ, Brennand KJ, Roussos P, Schimenti JC, Friedman AK, Shen L, Blitzer RD, Robison AJ, Crabtree GR, Maze I. Fulton SL, et al. Among authors: crabtree gr. Nat Commun. 2022 Oct 26;13(1):6384. doi: 10.1038/s41467-022-34200-0. Nat Commun. 2022. PMID: 36289231 Free PMC article.
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.
Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR. Arron JR, et al. Among authors: crabtree gr. Nature. 2006 Jun 1;441(7093):595-600. doi: 10.1038/nature04678. Epub 2006 Mar 22. Nature. 2006. PMID: 16554754
BAF complexes facilitate decatenation of DNA by topoisomerase IIα.
Dykhuizen EC, Hargreaves DC, Miller EL, Cui K, Korshunov A, Kool M, Pfister S, Cho YJ, Zhao K, Crabtree GR. Dykhuizen EC, et al. Among authors: crabtree gr. Nature. 2013 May 30;497(7451):624-7. doi: 10.1038/nature12146. Epub 2013 May 22. Nature. 2013. PMID: 23698369 Free PMC article.
Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism.
Wenderski W, Wang L, Krokhotin A, Walsh JJ, Li H, Shoji H, Ghosh S, George RD, Miller EL, Elias L, Gillespie MA, Son EY, Staahl BT, Baek ST, Stanley V, Moncada C, Shipony Z, Linker SB, Marchetto MCN, Gage FH, Chen D, Sultan T, Zaki MS, Ranish JA, Miyakawa T, Luo L, Malenka RC, Crabtree GR, Gleeson JG. Wenderski W, et al. Among authors: crabtree gr. Proc Natl Acad Sci U S A. 2020 May 5;117(18):10055-10066. doi: 10.1073/pnas.1908238117. Epub 2020 Apr 20. Proc Natl Acad Sci U S A. 2020. PMID: 32312822 Free PMC article.
LSH mediates gene repression through macroH2A deposition.
Ni K, Ren J, Xu X, He Y, Finney R, Braun SMG, Hathaway NA, Crabtree GR, Muegge K. Ni K, et al. Among authors: crabtree gr. Nat Commun. 2020 Nov 6;11(1):5647. doi: 10.1038/s41467-020-19159-0. Nat Commun. 2020. PMID: 33159050 Free PMC article.
291 results