Koniuszewski F - Search Results

1

Novel alpha6 preferring GABA-A receptor ligands based on loreclezole.

Simeone X, Ernst M, Seidel T, Heider J, Enz D, Monticelli S, Vogel FD, Koniuszewski F, Langer T, Scholze P, Pace V, Miele M. Simeone X, et al. Among authors: koniuszewski f. Eur J Med Chem. 2022 Dec 15;244:114780. doi: 10.1016/j.ejmech.2022.114780. Epub 2022 Sep 17. Eur J Med Chem. 2022. PMID: 36279694

2

GABA_A Receptor Ligands Often Interact with Binding Sites in the Transmembrane Domain and in the Extracellular Domain-Can the Promiscuity Code Be Cracked?

Iorio MT, Vogel FD, Koniuszewski F, Scholze P, Rehman S, Simeone X, Schnürch M, Mihovilovic MD, Ernst M. Iorio MT, et al. Among authors: koniuszewski f. Int J Mol Sci. 2020 Jan 3;21(1):334. doi: 10.3390/ijms21010334. Int J Mol Sci. 2020. PMID: 31947863 Free PMC article.

3

A Benzodiazepine Ligand with Improved GABA_A Receptor α5-Subunit Selectivity Driven by Interactions with Loop C.

Simeone X, Koniuszewski F, Müllegger M, Smetka A, Steudle F, Puthenkalam R, Ernst M, Scholze P. Simeone X, et al. Among authors: koniuszewski f. Mol Pharmacol. 2021 Jan;99(1):39-48. doi: 10.1124/molpharm.120.000067. Epub 2020 Dec 2. Mol Pharmacol. 2021. PMID: 33268553

4

Structure-Guided Computational Methods Predict Multiple Distinct Binding Modes for Pyrazoloquinolinones in GABA_A Receptors.

Fabjan J, Koniuszewski F, Schaar B, Ernst M. Fabjan J, et al. Among authors: koniuszewski f. Front Neurosci. 2021 Jan 15;14:611953. doi: 10.3389/fnins.2020.611953. eCollection 2020. Front Neurosci. 2021. PMID: 33519364 Free PMC article.

5

Tricyclic antipsychotics and antidepressants can inhibit α5-containing GABA_A receptors by two distinct mechanisms.

Bampali K, Koniuszewski F, Silva LL, Rehman S, Vogel FD, Seidel T, Scholze P, Zirpel F, Garon A, Langer T, Willeit M, Ernst M. Bampali K, et al. Among authors: koniuszewski f. Br J Pharmacol. 2022 Jul;179(14):3675-3692. doi: 10.1111/bph.15807. Epub 2022 Mar 7. Br J Pharmacol. 2022. PMID: 35088415 Free PMC article.

6

A de novo missense variant in GABRA4 alters receptor function in an epileptic and neurodevelopmental phenotype.

Vogel FD, Krenn M, Westphal DS, Graf E, Wagner M, Leiz S, Koniuszewski F, Augé-Stock M, Kramer G, Scholze P, Ernst M. Vogel FD, et al. Among authors: koniuszewski f. Epilepsia. 2022 Apr;63(4):e35-e41. doi: 10.1111/epi.17188. Epub 2022 Feb 12. Epilepsia. 2022. PMID: 35152403 Free PMC article.

7

Molecular Mingling: Multimodal Predictions of Ligand Promiscuity in Pentameric Ligand-Gated Ion Channels.

Koniuszewski F, Vogel FD, Bampali K, Fabjan J, Seidel T, Scholze P, Schmiedhofer PB, Langer T, Ernst M. Koniuszewski F, et al. Front Mol Biosci. 2022 May 9;9:860246. doi: 10.3389/fmolb.2022.860246. eCollection 2022. Front Mol Biosci. 2022. PMID: 35615739 Free PMC article.

8

Cys-loop receptors on cannabinoids: All high?

Schmiedhofer P, Vogel FD, Koniuszewski F, Ernst M. Schmiedhofer P, et al. Among authors: koniuszewski f. Front Physiol. 2022 Nov 9;13:1044575. doi: 10.3389/fphys.2022.1044575. eCollection 2022. Front Physiol. 2022. PMID: 36439263 Free PMC article.

9

GABA_A receptor-mediated seizure liabilities: a mixed-methods screening approach.

Bampali K, Koniuszewski F, Vogel FD, Fabjan J, Andronis C, Lekka E, Virvillis V, Seidel T, Delaunois A, Royer L, Rolf MG, Giuliano C, Traebert M, Roussignol G, Fric-Bordat M, Mazelin-Winum L, Bryant SD, Langer T, Ernst M. Bampali K, et al. Among authors: koniuszewski f. Cell Biol Toxicol. 2023 Dec;39(6):2793-2819. doi: 10.1007/s10565-023-09803-y. Epub 2023 Apr 24. Cell Biol Toxicol. 2023. PMID: 37093397 Free PMC article.

10

Probes for the heterogeneity of muscimol binding sites in rat brain.

Müller V, Ernst M, Baykuchkarova A, Koniuszewski F, Bampali K, Seidel T, Scholze P. Müller V, et al. Among authors: koniuszewski f. Front Pharmacol. 2024 Mar 14;15:1368527. doi: 10.3389/fphar.2024.1368527. eCollection 2024. Front Pharmacol. 2024. PMID: 38549678 Free PMC article.

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