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CD271 mRNA/hnRNPA2B1 complex promotes proliferation and stemness in oral and head and neck squamous cell carcinoma.
Mochizuki M, Shibuya-Takahashi R, Kanno SI, Adachi S, Fujimori H, Nakazato A, Fujii K, Morita S, Saijoh S, Yamazaki T, Imai T, Asada Y, Yamaguchi K, Yasuda J, Shindo N, Sugamura K, Tamai K. Mochizuki M, et al. Among authors: shibuya takahashi r. Cancer Sci. 2024 May 6. doi: 10.1111/cas.16187. Online ahead of print. Cancer Sci. 2024. PMID: 38710200 Free article.
FAXC interacts with ANXA2 and SRC in mitochondria and promotes tumorigenesis in cholangiocarcinoma.
Fujimori H, Shima-Nakamura M, Kanno SI, Shibuya-Takahashi R, Mochizuki M, Mizuma M, Unno M, Wakui Y, Abue M, Iwai W, Fukushi D, Satoh K, Yamaguchi K, Shindo N, Yasuda J, Tamai K. Fujimori H, et al. Among authors: shibuya takahashi r. Cancer Sci. 2024 Jun;115(6):1896-1909. doi: 10.1111/cas.16140. Epub 2024 Mar 13. Cancer Sci. 2024. PMID: 38480477 Free PMC article.
CD271 promotes proliferation and migration in bladder cancer.
Myoen S, Mochizuki M, Shibuya-Takahashi R, Fujimori H, Shindo N, Yamaguchi K, Yasuda J, Abe J, Imai T, Sato I, Adachi H, Kawamura S, Ito A, Tamai K. Myoen S, et al. Among authors: shibuya takahashi r. Genes Cells. 2024 Jan;29(1):73-85. doi: 10.1111/gtc.13087. Epub 2023 Nov 28. Genes Cells. 2024. PMID: 38016691
BEX2 is poor prognostic factor and required for cancer stemness in gastric cancer.
Yasumoto A, Fujimori H, Mochizuki M, Shibuya-Takahashi R, Nakamura-Shima M, Shindo N, Yamaguchi K, Fukushi D, Wakui Y, Sugai T, Iwai W, Abue M, Sato I, Satoh K, Katayose Y, Yasuda J, Shibata C, Tamai K. Yasumoto A, et al. Among authors: shibuya takahashi r. Biochem Biophys Res Commun. 2023 May 7;655:59-67. doi: 10.1016/j.bbrc.2023.03.025. Epub 2023 Mar 11. Biochem Biophys Res Commun. 2023. PMID: 36933308
RELA is required for CD271 expression and stem-like characteristics in hypopharyngeal cancer.
Nakazato A, Mochizuki M, Shibuya-Takahashi R, Fujimori H, Fujii K, Saijoh S, Morita S, Yamazaki T, Imai T, Sato I, Satoh K, Yamaguchi K, Sugamura K, Yasuda J, Matsuura K, Shojaku H, Asada Y, Tamai K. Nakazato A, et al. Among authors: shibuya takahashi r. Sci Rep. 2022 Oct 22;12(1):17751. doi: 10.1038/s41598-022-22736-6. Sci Rep. 2022. PMID: 36273237 Free PMC article.
Establishment of a monoclonal antibody against glycosylated CD271 specific for cancer cells in immunohistochemistry.
Fujii K, Morita S, Mochizuki M, Shibuya-Takahashi R, Fujimori H, Yamaguchi K, Abe J, Yamazaki T, Imai T, Sugamura K, Yasuda J, Satoh K, Sato I, Saito-Koyama R, Fujishima F, Sasano H, Kato Y, Matsuura K, Asada Y, Tamai K. Fujii K, et al. Among authors: shibuya takahashi r. Cancer Sci. 2022 Aug;113(8):2878-2887. doi: 10.1111/cas.15340. Epub 2022 Apr 18. Cancer Sci. 2022. PMID: 35343032 Free PMC article.
BEX2 is required for maintaining dormant cancer stem cell in hepatocellular carcinoma.
Fukushi D, Shibuya-Takahashi R, Mochizuki M, Fujimori H, Kogure T, Sugai T, Iwai W, Wakui Y, Abue M, Murakami K, Nakamura Y, Yasuda J, Yamaguchi K, Sugamura K, Shibata C, Katayose Y, Satoh K, Tamai K. Fukushi D, et al. Among authors: shibuya takahashi r. Cancer Sci. 2021 Nov;112(11):4580-4592. doi: 10.1111/cas.15115. Epub 2021 Sep 4. Cancer Sci. 2021. PMID: 34424582 Free PMC article.
Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein.
Saijoh S, Nakamura-Shima M, Shibuya-Takahashi R, Ito R, Sugawara A, Yamazaki T, Imai T, Asada Y, Matsuura K, Iwai W, Wakui Y, Abue M, Kawamura S, Katayose Y, Fujimori H, Mochizuki M, Yasuda J, Yamaguchi K, Sugamura K, Satoh K, Katori Y, Tamai K. Saijoh S, et al. Among authors: shibuya takahashi r. Biochem Biophys Res Commun. 2021 Jan 22;537:132-139. doi: 10.1016/j.bbrc.2020.11.022. Epub 2021 Jan 4. Biochem Biophys Res Commun. 2021. PMID: 33412384
BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma.
Tamai K, Nakamura-Shima M, Shibuya-Takahashi R, Kanno SI, Yasui A, Mochizuki M, Iwai W, Wakui Y, Abue M, Yamamoto K, Miura K, Mizuma M, Unno M, Kawamura S, Sato I, Yasuda J, Yamaguchi K, Sugamura K, Satoh K. Tamai K, et al. Among authors: shibuya takahashi r. Sci Rep. 2020 Dec 9;10(1):21592. doi: 10.1038/s41598-020-78539-0. Sci Rep. 2020. PMID: 33299012 Free PMC article.
Establishment of a Monoclonal Antibody That Recognizes Cysteine-Rich Domain 1 of Human CD271.
Morita S, Mochizuki M, Shibuya-Takahashi R, Nakamura-Shima M, Yamazaki T, Imai T, Asada Y, Matsuura K, Kawamura S, Yamaguchi K, Yasuda J, Sugamura K, Katori Y, Satoh K, Tamai K. Morita S, et al. Among authors: shibuya takahashi r. Monoclon Antib Immunodiagn Immunother. 2020 Feb;39(1):6-11. doi: 10.1089/mab.2019.0040. Monoclon Antib Immunodiagn Immunother. 2020. PMID: 32069133