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Page 1
CD27 is required for protective lytic EBV antigen-specific CD8+ T-cell expansion.
Deng Y, Chatterjee B, Zens K, Zdimerova H, Müller A, Schuhmachers P, Ligeon LA, Bongiovanni A, Capaul R, Zbinden A, Holler A, Stauss H, Hammerschmidt W, Münz C. Deng Y, et al. Among authors: schuhmachers p. Blood. 2021 Jun 10;137(23):3225-3236. doi: 10.1182/blood.2020009482. Blood. 2021. PMID: 33827115 Free PMC article.
PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice.
Zhang X, Schuhmachers P, Mourão A, Giansanti P, Murer A, Thumann S, Kuklik-Roos C, Beer S, Hauck SM, Hammerschmidt W, Küppers R, Kuster B, Raab M, Strebhardt K, Sattler M, Münz C, Kempkes B. Zhang X, et al. Among authors: schuhmachers p. EMBO Rep. 2021 Dec 6;22(12):e53007. doi: 10.15252/embr.202153007. Epub 2021 Oct 4. EMBO Rep. 2021. PMID: 34605140 Free PMC article.
A metabolic dependency of EBV can be targeted to hinder B cell transformation.
Müller-Durovic B, Jäger J, Engelmann C, Schuhmachers P, Altermatt S, Schlup Y, Duthaler U, Makowiec C, Unterstab G, Roffeis S, Xhafa E, Assmann N, Trulsson F, Steiner R, Edwards-Hicks J, West J, Turner L, Develioglu L, Ivanek R, Azzi T, Dehio P, Berger C; Swiss Transplant Cohort Study#; Kuzmin D, Saboz S, Mautner J, Löliger J, Geigges M, Palianina D, Khanna N, Dirnhofer S, Münz C, Bantug GR, Hess C. Müller-Durovic B, et al. Among authors: schuhmachers p. Science. 2024 May 23:eadk4898. doi: 10.1126/science.adk4898. Online ahead of print. Science. 2024. PMID: 38781354
MHC class II-deficient mice allow functional human CD4+ T-cell development.
Läderach F, Zdimerova H, Rieble L, Schuhmachers P, Engelmann C, Valencia-Camargo AD, Kirchmeier D, Böni M, Münz C. Läderach F, et al. Among authors: schuhmachers p. Eur J Immunol. 2023 Jul;53(7):e2250313. doi: 10.1002/eji.202250313. Epub 2023 May 12. Eur J Immunol. 2023. PMID: 37118896