Wong CO - Search Results

1

Loss of Activity-Induced Mitochondrial ATP Production Underlies the Synaptic Defects in a Drosophila Model of ALS.

Karagas NE, Gupta R, Rastegari E, Tan KL, Leung HH, Bellen HJ, Venkatachalam K, Wong CO. Karagas NE, et al. Among authors: wong co. J Neurosci. 2022 Oct 19;42(42):8019-8037. doi: 10.1523/JNEUROSCI.2456-21.2022. Epub 2022 Sep 8. J Neurosci. 2022. PMID: 36261266 Free PMC article.

2

Motor neurons from ALS patients with mutations in C9ORF72 and SOD1 exhibit distinct transcriptional landscapes.

Wong CO, Venkatachalam K. Wong CO, et al. Hum Mol Genet. 2019 Aug 15;28(16):2799-2810. doi: 10.1093/hmg/ddz104. Hum Mol Genet. 2019. PMID: 31107959 Free PMC article.

3

Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in Drosophila.

Martelli F, Zhongyuan Z, Wang J, Wong CO, Karagas NE, Roessner U, Rupasinghe T, Venkatachalam K, Perry T, Bellen HJ, Batterham P. Martelli F, et al. Among authors: wong co. Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25840-25850. doi: 10.1073/pnas.2011828117. Epub 2020 Sep 28. Proc Natl Acad Sci U S A. 2020. PMID: 32989137 Free PMC article.

4

Regulation of longevity by depolarization-induced activation of PLC-β-IP₃R signaling in neurons.

Wong CO, Karagas NE, Jung J, Wang Q, Rousseau MA, Chao Y, Insolera R, Soppina P, Collins CA, Zhou Y, Hancock JF, Zhu MX, Venkatachalam K. Wong CO, et al. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2004253118. doi: 10.1073/pnas.2004253118. Proc Natl Acad Sci U S A. 2021. PMID: 33859040 Free PMC article.

5

Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies.

Martelli F, Hernandes NH, Zuo Z, Wang J, Wong CO, Karagas NE, Roessner U, Rupasinghe T, Robin C, Venkatachalam K, Perry T, Batterham P, Bellen HJ. Martelli F, et al. Among authors: wong co. Elife. 2022 Feb 22;11:e73812. doi: 10.7554/eLife.73812. Elife. 2022. PMID: 35191376 Free PMC article.

6

Drosophila TRPML is required for TORC1 activation.

Wong CO, Li R, Montell C, Venkatachalam K. Wong CO, et al. Curr Biol. 2012 Sep 11;22(17):1616-21. doi: 10.1016/j.cub.2012.06.055. Epub 2012 Aug 2. Curr Biol. 2012. PMID: 22863314 Free PMC article.

7

A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission.

Wong CO, Chen K, Lin YQ, Chao Y, Duraine L, Lu Z, Yoon WH, Sullivan JM, Broadhead GT, Sumner CJ, Lloyd TE, Macleod GT, Bellen HJ, Venkatachalam K. Wong CO, et al. Neuron. 2014 Nov 19;84(4):764-77. doi: 10.1016/j.neuron.2014.09.030. Epub 2014 Oct 30. Neuron. 2014. PMID: 25451193 Free PMC article.

8

HRAS-driven cancer cells are vulnerable to TRPML1 inhibition.

Jung J, Cho KJ, Naji AK, Clemons KN, Wong CO, Villanueva M, Gregory S, Karagas NE, Tan L, Liang H, Rousseau MA, Tomasevich KM, Sikora AG, Levental I, van der Hoeven D, Zhou Y, Hancock JF, Venkatachalam K. Jung J, et al. Among authors: wong co. EMBO Rep. 2019 Apr;20(4):e46685. doi: 10.15252/embr.201846685. Epub 2019 Feb 20. EMBO Rep. 2019. PMID: 30787043 Free PMC article.

9

The role of TRPMLs in endolysosomal trafficking and function.

Venkatachalam K, Wong CO, Zhu MX. Venkatachalam K, et al. Among authors: wong co. Cell Calcium. 2015 Jul;58(1):48-56. doi: 10.1016/j.ceca.2014.10.008. Epub 2014 Oct 28. Cell Calcium. 2015. PMID: 25465891 Free PMC article. Review.

10

Diminished MTORC1-Dependent JNK Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction.

Wong CO, Palmieri M, Li J, Akhmedov D, Chao Y, Broadhead GT, Zhu MX, Berdeaux R, Collins CA, Sardiello M, Venkatachalam K. Wong CO, et al. Cell Rep. 2015 Sep 29;12(12):2009-20. doi: 10.1016/j.celrep.2015.08.047. Epub 2015 Sep 17. Cell Rep. 2015. PMID: 26387958 Free PMC article.

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