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Intradermal vaccination of HPV-16 E6 synthetic peptides conjugated to an optimized Toll-like receptor 2 ligand shows safety and potent T cell immunogenicity in patients with HPV-16 positive (pre-)malignant lesions.
J Immunother Cancer. 2022 Oct;10(10):e005016. doi: 10.1136/jitc-2022-005016.
J Immunother Cancer. 2022.
PMID: 36261215
Free PMC article.
Clinical Trial.
Strong vaccine responses during chemotherapy are associated with prolonged cancer survival.
Melief CJM, Welters MJP, Vergote I, Kroep JR, Kenter GG, Ottevanger PB, Tjalma WAA, Denys H, van Poelgeest MIE, Nijman HW, Reyners AKL, Velu T, Goffin F, Lalisang RI, Loof NM, Boekestijn S, Krebber WJ, Hooftman L, Visscher S, Blumenstein BA, Stead RB, Gerritsen W, van der Burg SH.
Melief CJM, et al. Among authors: boekestijn s.
Sci Transl Med. 2020 Mar 18;12(535):eaaz8235. doi: 10.1126/scitranslmed.aaz8235.
Sci Transl Med. 2020.
PMID: 32188726
Free article.
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Photochemical Internalization Enhanced Vaccination Is Safe, and Gives Promising Cellular Immune Responses to an HPV Peptide-Based Vaccine in a Phase I Clinical Study in Healthy Volunteers.
Otterhaug T, Janetzki S, Welters MJP, Håkerud M, Nedberg AG, Edwards VT, Boekestijn S, Loof NM, Selbo PK, Olivecrona H, van der Burg SH, Høgset A.
Otterhaug T, et al. Among authors: boekestijn s.
Front Immunol. 2021 Jan 8;11:576756. doi: 10.3389/fimmu.2020.576756. eCollection 2020.
Front Immunol. 2021.
PMID: 33488576
Free PMC article.
Clinical Trial.
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CD161 expression and regulation defines rapidly responding effector CD4+ T cells associated with improved survival in HPV16-associated tumors.
Duurland CL, Santegoets SJ, Abdulrahman Z, Loof NM, Sturm G, Wesselink TH, Arens R, Boekestijn S, Ehsan I, van Poelgeest MIE, Finotello F, Hackl H, Trajanoski Z, Ten Dijke P, Braud VM, Welters MJP, van der Burg SH.
Duurland CL, et al. Among authors: boekestijn s.
J Immunother Cancer. 2022 Jan;10(1):e003995. doi: 10.1136/jitc-2021-003995.
J Immunother Cancer. 2022.
PMID: 35039463
Free PMC article.
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Therapeutic Vaccination against Human Papillomavirus Type 16 for the Treatment of High-Grade Anal Intraepithelial Neoplasia in HIV+ Men.
Gosens KCM, van der Burg SH, Welters MJP, Boekestijn S, Loof NM, Quint WGV, van Noesel CJM, van der Wal AC, Richel O, Krebber WJTA, Melief CJM, de Vries HJC, Prins JM.
Gosens KCM, et al. Among authors: boekestijn s.
Clin Cancer Res. 2023 Oct 13;29(20):4109-4117. doi: 10.1158/1078-0432.CCR-22-3361.
Clin Cancer Res. 2023.
PMID: 37540563
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Continuous Light Does Not Affect Atherosclerosis in APOE*3-Leiden.CETP Mice.
Schilperoort M, van den Berg R, Coomans CP, Khedoe PPSJ, Ramkisoensing A, Boekestijn S, Wang Y, Berbée JFP, Meijer JH, Biermasz NR, Rensen PCN, Kooijman S.
Schilperoort M, et al. Among authors: boekestijn s.
J Biol Rhythms. 2020 Dec;35(6):598-611. doi: 10.1177/0748730420951320. Epub 2020 Sep 11.
J Biol Rhythms. 2020.
PMID: 32915671
Free PMC article.
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Timed adoptive T cell transfer during chemotherapy in patients with recurrent platinum-sensitive epithelial ovarian cancer.
Verdegaal EME, Santegoets SJ, Welters MJP, de Bruin L, Visser M, van der Minne CE, de Kok PM, Loof NM, Boekestijn S, Roozen I, Westra IM, Meij P, Van der Burg SH, Kroep JR.
Verdegaal EME, et al. Among authors: boekestijn s.
J Immunother Cancer. 2023 Nov;11(11):e007697. doi: 10.1136/jitc-2023-007697.
J Immunother Cancer. 2023.
PMID: 37949617
Free PMC article.
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