Ayikpoe RS - Search Results

1

A scalable platform to discover antimicrobials of ribosomal origin.

Ayikpoe RS, Shi C, Battiste AJ, Eslami SM, Ramesh S, Simon MA, Bothwell IR, Lee H, Rice AJ, Ren H, Tian Q, Harris LA, Sarksian R, Zhu L, Frerk AM, Precord TW, van der Donk WA, Mitchell DA, Zhao H. Ayikpoe RS, et al. Nat Commun. 2022 Oct 17;13(1):6135. doi: 10.1038/s41467-022-33890-w. Nat Commun. 2022. PMID: 36253467 Free PMC article.

2

Peptide backbone modifications in lanthipeptides.

Ayikpoe RS, van der Donk WA. Ayikpoe RS, et al. Methods Enzymol. 2021;656:573-621. doi: 10.1016/bs.mie.2021.04.012. Epub 2021 May 7. Methods Enzymol. 2021. PMID: 34325799

3

Macrocyclization and Backbone Rearrangement During RiPP Biosynthesis by a SAM-Dependent Domain-of-Unknown-Function 692.

Ayikpoe RS, Zhu L, Chen JY, Ting CP, van der Donk WA. Ayikpoe RS, et al. ACS Cent Sci. 2023 Apr 24;9(5):1008-1018. doi: 10.1021/acscentsci.3c00160. eCollection 2023 May 24. ACS Cent Sci. 2023. PMID: 37252350 Free PMC article.

4

Occurrence, function, and biosynthesis of mycofactocin.

Ayikpoe R, Govindarajan V, Latham JA. Ayikpoe R, et al. Appl Microbiol Biotechnol. 2019 Apr;103(7):2903-2912. doi: 10.1007/s00253-019-09684-4. Epub 2019 Feb 18. Appl Microbiol Biotechnol. 2019. PMID: 30778644 Free PMC article. Review.

5

MftD Catalyzes the Formation of a Biologically Active Redox Center in the Biosynthesis of the Ribosomally Synthesized and Post-translationally Modified Redox Cofactor Mycofactocin.

Ayikpoe RS, Latham JA. Ayikpoe RS, et al. J Am Chem Soc. 2019 Aug 28;141(34):13582-13591. doi: 10.1021/jacs.9b06102. Epub 2019 Aug 15. J Am Chem Soc. 2019. PMID: 31381312 Free PMC article.

6

Mechanistic elucidation of the mycofactocin-biosynthetic radical S-adenosylmethionine protein, MftC.

Khaliullin B, Ayikpoe R, Tuttle M, Latham JA. Khaliullin B, et al. J Biol Chem. 2017 Aug 4;292(31):13022-13033. doi: 10.1074/jbc.M117.795682. Epub 2017 Jun 20. J Biol Chem. 2017. PMID: 28634235 Free PMC article.

7

Mycofactocin Biosynthesis Proceeds through 3-Amino-5-[( p-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidinone (AHDP); Direct Observation of MftE Specificity toward MftA.

Ayikpoe R, Salazar J, Majestic B, Latham JA. Ayikpoe R, et al. Biochemistry. 2018 Sep 18;57(37):5379-5383. doi: 10.1021/acs.biochem.8b00816. Epub 2018 Sep 6. Biochemistry. 2018. PMID: 30183269 Free PMC article.

8

Spectroscopic and Electrochemical Characterization of the Mycofactocin Biosynthetic Protein, MftC, Provides Insight into Its Redox Flipping Mechanism.

Ayikpoe R, Ngendahimana T, Langton M, Bonitatibus S, Walker LM, Eaton SS, Eaton GR, Pandelia ME, Elliott SJ, Latham JA. Ayikpoe R, et al. Biochemistry. 2019 Feb 19;58(7):940-950. doi: 10.1021/acs.biochem.8b01082. Epub 2019 Jan 25. Biochemistry. 2019. PMID: 30628436 Free PMC article.

9

Structural insights for vanadium catecholates and iron‑sulfur clusters obtained from multiple data analysis methods applied to electron spin relaxation data.

Ngendahimana T, Ayikpoe R, Latham JA, Eaton GR, Eaton SS. Ngendahimana T, et al. J Inorg Biochem. 2019 Dec;201:110806. doi: 10.1016/j.jinorgbio.2019.110806. Epub 2019 Sep 2. J Inorg Biochem. 2019. PMID: 31505439 Free PMC article.

10

A remarkable transformation catalyzed by a domain-of-unknown-function 692 during the biosynthesis of a new RiPP natural product.

Ayikpoe RS, Zhu L, Chen JY, Ting CP, van der Donk WA. Ayikpoe RS, et al. bioRxiv [Preprint]. 2023 Feb 7:2023.02.06.527370. doi: 10.1101/2023.02.06.527370. bioRxiv. 2023. PMID: 36798408 Free PMC article. Preprint.

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