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Depletion of exhausted alloreactive T cells enables targeting of stem-like memory T cells to generate tumor-specific immunity.
Sci Immunol. 2022 Oct 21;7(76):eabo3420. doi: 10.1126/sciimmunol.abo3420. Epub 2022 Oct 14.
Sci Immunol. 2022.
PMID: 36240285
Free PMC article.
TIGIT inhibition and lenalidomide synergistically promote antimyeloma immune responses after stem cell transplantation in mice.
Minnie SA, Waltner OG, Ensbey KS, Olver SD, Collinge AD, Sester DP, Schmidt CR, Legg SR, Takahashi S, Nemychenkov NS, Sekiguchi T, Driessens G, Zhang P, Koyama M, Spencer A, Holmberg LA, Furlan SN, Varelias A, Hill GR.
Minnie SA, et al.
J Clin Invest. 2023 Feb 15;133(4):e157907. doi: 10.1172/JCI157907.
J Clin Invest. 2023.
PMID: 36512425
Free PMC article.
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Regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation.
Takahashi S, Minnie SA, Ensbey KS, Schmidt CR, Sekiguchi T, Legg SRW, Zhang P, Koyama M, Olver SD, Collinge AD, Keshmiri S, Comstock ML, Varelias A, Green DJ, Hill GR.
Takahashi S, et al. Among authors: legg srw.
Blood. 2024 Apr 18;143(16):1656-1669. doi: 10.1182/blood.2023022000.
Blood. 2024.
PMID: 38295333
Free PMC article.
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IL-6-mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation.
Zhang P, Fleming P, Andoniou CE, Waltner OG, Bhise SS, Martins JP, McEnroe BA, Voigt V, Daly S, Kuns RD, Ekwe AP, Henden AS, Saldan A, Olver S, Varelias A, Smith C, Schmidt CR, Ensbey KS, Legg SR, Sekiguchi T, Minnie SA, Gradwell M, Wagenaar I, Clouston AD, Koyama M, Furlan SN, Kennedy GA, Ward ES, Degli-Esposti MA, Hill GR, Tey SK.
Zhang P, et al.
J Clin Invest. 2024 Apr 1;134(7):e174184. doi: 10.1172/JCI174184.
J Clin Invest. 2024.
PMID: 38557487
Free PMC article.
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TIM-3+ CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies.
Minnie SA, Waltner OG, Zhang P, Takahashi S, Nemychenkov NS, Ensbey KS, Schmidt CR, Legg SRW, Comstock M, Boiko JR, Nelson E, Bhise SS, Wilkens AB, Koyama M, Dhodapkar MV, Chesi M, Riddell SR, Green DJ, Spencer A, Furlan SN, Hill GR.
Minnie SA, et al. Among authors: legg srw.
Sci Immunol. 2024 Apr 19;9(94):eadg1094. doi: 10.1126/sciimmunol.adg1094. Epub 2024 Apr 19.
Sci Immunol. 2024.
PMID: 38640253
Free PMC article.
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Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation.
Bragg RM, Coffey SR, Cantle JP, Hu S, Singh S, Legg SRW, McHugh CA, Toor A, Zeitlin SO, Kwak S, Howland D, Vogt TF, Monga SP, Carroll JB.
Bragg RM, et al. Among authors: legg srw.
bioRxiv [Preprint]. 2023 Jun 26:2023.06.24.546334. doi: 10.1101/2023.06.24.546334.
bioRxiv. 2023.
PMID: 37425835
Free PMC article.
Updated.
Preprint.
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Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations.
Malaiya S, Cortes-Gutierrez M, Herb BR, Coffey SR, Legg SRW, Cantle JP, Colantuoni C, Carroll JB, Ament SA.
Malaiya S, et al. Among authors: legg srw.
J Neurosci. 2021 Jun 23;41(25):5534-5552. doi: 10.1523/JNEUROSCI.2074-20.2021. Epub 2021 May 19.
J Neurosci. 2021.
PMID: 34011527
Free PMC article.
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Early Detection of Apathetic Phenotypes in Huntington's Disease Knock-in Mice Using Open Source Tools.
Minnig S, Bragg RM, Tiwana HS, Solem WT, Hovander WS, Vik ES, Hamilton M, Legg SRW, Shuttleworth DD, Coffey SR, Cantle JP, Carroll JB.
Minnig S, et al. Among authors: legg srw.
Sci Rep. 2018 Feb 2;8(1):2304. doi: 10.1038/s41598-018-20607-7.
Sci Rep. 2018.
PMID: 29396492
Free PMC article.
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