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The VEGAS Platform Is Unsuitable for Mammalian Directed Evolution.
Denes CE, Cole AJ, Tran MTN, Mohd Khalid MKN, Hewitt AW, Hesselson D, Neely GG. Denes CE, et al. Among authors: hewitt aw. ACS Synth Biol. 2022 Oct 21;11(10):3544-3549. doi: 10.1021/acssynbio.2c00460. Epub 2022 Oct 11. ACS Synth Biol. 2022. PMID: 36219697
Utility of Self-Destructing CRISPR/Cas Constructs for Targeted Gene Editing in the Retina.
Li F, Hung SSC, Mohd Khalid MKN, Wang JH, Chrysostomou V, Wong VHY, Singh V, Wing K, Tu L, Bender JA, Pébay A, King AE, Cook AL, Wong RCB, Bui BV, Hewitt AW, Liu GS. Li F, et al. Among authors: hewitt aw. Hum Gene Ther. 2019 Nov;30(11):1349-1360. doi: 10.1089/hum.2019.021. Epub 2019 Oct 25. Hum Gene Ther. 2019. PMID: 31373227
A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus.
Hardcastle AJ, Liskova P, Bykhovskaya Y, McComish BJ, Davidson AE, Inglehearn CF, Li X, Choquet H, Habeeb M, Lucas SEM, Sahebjada S, Pontikos N, Lopez KER, Khawaja AP, Ali M, Dudakova L, Skalicka P, Van Dooren BTH, Geerards AJM, Haudum CW, Faro VL, Tenen A, Simcoe MJ, Patasova K, Yarrand D, Yin J, Siddiqui S, Rice A, Farraj LA, Chen YI, Rahi JS, Krauss RM, Theusch E, Charlesworth JC, Szczotka-Flynn L, Toomes C, Meester-Smoor MA, Richardson AJ, Mitchell PA, Taylor KD, Melles RB, Aldave AJ, Mills RA, Cao K, Chan E, Daniell MD, Wang JJ, Rotter JI, Hewitt AW, MacGregor S, Klaver CCW, Ramdas WD, Craig JE, Iyengar SK, O'Brart D, Jorgenson E, Baird PN, Rabinowitz YS, Burdon KP, Hammond CJ, Tuft SJ, Hysi PG. Hardcastle AJ, et al. Among authors: hewitt aw. Commun Biol. 2021 Mar 1;4(1):266. doi: 10.1038/s42003-021-01784-0. Commun Biol. 2021. PMID: 33649486 Free PMC article.
Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells.
Neavin D, Nguyen Q, Daniszewski MS, Liang HH, Chiu HS, Wee YK, Senabouth A, Lukowski SW, Crombie DE, Lidgerwood GE, Hernández D, Vickers JC, Cook AL, Palpant NJ, Pébay A, Hewitt AW, Powell JE. Neavin D, et al. Among authors: hewitt aw. Genome Biol. 2021 Mar 5;22(1):76. doi: 10.1186/s13059-021-02293-3. Genome Biol. 2021. PMID: 33673841 Free PMC article.
Retinal ganglion cell-specific genetic regulation in primary open-angle glaucoma.
Daniszewski M, Senabouth A, Liang HH, Han X, Lidgerwood GE, Hernández D, Sivakumaran P, Clarke JE, Lim SY, Lees JG, Rooney L, Gulluyan L, Souzeau E, Graham SL, Chan CL, Nguyen U, Farbehi N, Gnanasambandapillai V, McCloy RA, Clarke L, Kearns LS, Mackey DA, Craig JE, MacGregor S, Powell JE, Pébay A, Hewitt AW. Daniszewski M, et al. Among authors: hewitt aw. Cell Genom. 2022 Jun 8;2(6):100142. doi: 10.1016/j.xgen.2022.100142. eCollection 2022 Jun 8. Cell Genom. 2022. PMID: 36778138 Free PMC article.
Central corneal thickness is highly heritable: the twin eye studies.
Toh T, Liew SH, MacKinnon JR, Hewitt AW, Poulsen JL, Spector TD, Gilbert CE, Craig JE, Hammond CJ, Mackey DA. Toh T, et al. Among authors: hewitt aw. Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3718-22. doi: 10.1167/iovs.04-1497. Invest Ophthalmol Vis Sci. 2005. PMID: 16186354 Free article.
425 results