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Sphingosine-1-phosphate improves outcome of no-reflow acute myocardial infarction via sphingosine-1-phosphate receptor 1.
Polzin A, Dannenberg L, Benkhoff M, Barcik M, Keul P, Ayhan A, Weske S, Ahlbrecht S, Trojovsky K, Helten C, Haberkorn S, Flögel U, Zeus T, Müller T, Gräler MH, Kelm M, Levkau B. Polzin A, et al. Among authors: keul p. ESC Heart Fail. 2023 Feb;10(1):334-341. doi: 10.1002/ehf2.14176. Epub 2022 Oct 11. ESC Heart Fail. 2023. PMID: 36217778 Free PMC article.
High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor.
Theilmeier G, Schmidt C, Herrmann J, Keul P, Schäfers M, Herrgott I, Mersmann J, Larmann J, Hermann S, Stypmann J, Schober O, Hildebrand R, Schulz R, Heusch G, Haude M, von Wnuck Lipinski K, Herzog C, Schmitz M, Erbel R, Chun J, Levkau B. Theilmeier G, et al. Among authors: keul p. Circulation. 2006 Sep 26;114(13):1403-9. doi: 10.1161/CIRCULATIONAHA.105.607135. Epub 2006 Sep 18. Circulation. 2006. PMID: 16982942
Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor.
Walter DH, Rochwalsky U, Reinhold J, Seeger F, Aicher A, Urbich C, Spyridopoulos I, Chun J, Brinkmann V, Keul P, Levkau B, Zeiher AM, Dimmeler S, Haendeler J. Walter DH, et al. Among authors: keul p. Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):275-82. doi: 10.1161/01.ATV.0000254669.12675.70. Epub 2006 Dec 7. Arterioscler Thromb Vasc Biol. 2007. PMID: 17158356
Synthesis of new ligands for targeting the S1P1 receptor.
Schilson SS, Keul P, Shaikh RS, Schäfers M, Levkau B, Haufe G. Schilson SS, et al. Among authors: keul p. Bioorg Med Chem. 2015 Mar 1;23(5):1011-26. doi: 10.1016/j.bmc.2015.01.014. Epub 2015 Jan 16. Bioorg Med Chem. 2015. PMID: 25656338
41 results