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Hepatic glycerol shunt and glycerol-3-phosphate phosphatase control liver metabolism and glucodetoxification under hyperglycemia.
Al-Mass A, Poursharifi P, Peyot ML, Lussier R, Chenier I, Leung YH, Ghosh A, Oppong A, Possik E, Mugabo Y, Ahmad R, Sladek R, Murthy Madiraju SR, Al-Mulla F, Prentki M. Al-Mass A, et al. Among authors: murthy madiraju sr. Mol Metab. 2022 Dec;66:101609. doi: 10.1016/j.molmet.2022.101609. Epub 2022 Oct 2. Mol Metab. 2022. PMID: 36198384 Free PMC article.
Substantial PCSK9 inactivation in β-cells does not modify glucose homeostasis or insulin secretion in mice.
Peyot ML, Roubtsova A, Lussier R, Chamberland A, Essalmani R, Murthy Madiraju SR, Seidah NG, Prentki M, Prat A. Peyot ML, et al. Among authors: murthy madiraju sr. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Aug;1866(8):158968. doi: 10.1016/j.bbalip.2021.158968. Epub 2021 May 13. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 33992809
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.
Nguyen M, Marcellus RC, Roulston A, Watson M, Serfass L, Murthy Madiraju SR, Goulet D, Viallet J, Bélec L, Billot X, Acoca S, Purisima E, Wiegmans A, Cluse L, Johnstone RW, Beauparlant P, Shore GC. Nguyen M, et al. Among authors: murthy madiraju sr. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19512-7. doi: 10.1073/pnas.0709443104. Epub 2007 Nov 26. Proc Natl Acad Sci U S A. 2007. PMID: 18040043 Free PMC article.