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The structure-activity profile of mercaptobenzamides' anti-HIV activity suggests that thermodynamics of metabolism is more important than binding affinity to the target.
Nikolayevskiy H, Robello M, Scerba MT, Pasternak EH, Saha M, Hartman TL, Buchholz CA, Buckheit RW Jr, Durell SR, Appella DH. Nikolayevskiy H, et al. Among authors: saha m. Eur J Med Chem. 2019 Sep 15;178:818-837. doi: 10.1016/j.ejmech.2019.06.020. Epub 2019 Jun 9. Eur J Med Chem. 2019. PMID: 31252286 Free PMC article.
Preclinical evaluation of a mercaptobenzamide and its prodrug for NCp7-targeted inhibition of human immunodeficiency virus.
Hartman TL, Yang L, Helfrick AN, Hassink M, Shank NI, George Rosenker K, Scerba MT, Saha M, Hughes E, Wang AQ, Xu X, Gupta P, Buckheit RW Jr, Appella DH. Hartman TL, et al. Among authors: saha m. Antiviral Res. 2016 Oct;134:216-225. doi: 10.1016/j.antiviral.2016.08.022. Epub 2016 Aug 26. Antiviral Res. 2016. PMID: 27568924 Free PMC article.
1,044 results