Obst-Sander U - Search Results

1

Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.

Obst-Sander U, Ricci A, Kuhn B, Friess T, Koldewey P, Kuglstatter A, Hewings D, Goergler A, Steiner S, Rueher D, Imhoff MP, Raschetti N, Marty HP, Dietzig A, Rynn C, Ehler A, Burger D, Kornacker M, Schaffland JP, Herting F, Pao W, Bischoff JR, Martoglio B, Alice Nagel Y, Jaeschke G. Obst-Sander U, et al. J Med Chem. 2022 Oct 13;65(19):13052-13073. doi: 10.1021/acs.jmedchem.2c00893. Epub 2022 Sep 30. J Med Chem. 2022. PMID: 36178776

2

Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors.

Kühne H, Obst-Sander U, Kuhn B, Conte A, Ceccarelli SM, Neidhart W, Rudolph MG, Ottaviani G, Gasser R, So SS, Li S, Zhang X, Gao L, Myers M. Kühne H, et al. Among authors: obst sander u. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5092-5097. doi: 10.1016/j.bmcl.2016.08.071. Epub 2016 Aug 22. Bioorg Med Chem Lett. 2016. PMID: 27658368

3

What We Learned in 25 Years of Interactive Molecular Design Sessions.

Kuhn B, Haap W, Obst-Sander U, Kramer C, Stahl M. Kuhn B, et al. Among authors: obst sander u. ChemMedChem. 2021 Sep 16;16(18):2760-2763. doi: 10.1002/cmdc.202100351. Epub 2021 Aug 10. ChemMedChem. 2021. PMID: 34374230 Review.

4

Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity.

Groebke Zbinden K, Banner DW, Hilpert K, Himber J, Lavé T, Riederer MA, Stahl M, Tschopp TB, Obst-Sander U. Groebke Zbinden K, et al. Among authors: obst sander u. Bioorg Med Chem. 2006 Aug 1;14(15):5357-69. doi: 10.1016/j.bmc.2006.03.042. Epub 2006 Apr 18. Bioorg Med Chem. 2006. PMID: 16621574

5

Fluorine in medicinal chemistry.

Böhm HJ, Banner D, Bendels S, Kansy M, Kuhn B, Müller K, Obst-Sander U, Stahl M. Böhm HJ, et al. Chembiochem. 2004 May 3;5(5):637-43. doi: 10.1002/cbic.200301023. Chembiochem. 2004. PMID: 15122635 Review.

6

Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists.

Dehmlow H, Alvarez Sánchez R, Bachmann S, Bissantz C, Bliss F, Conde-Knape K, Graf M, Martin RE, Obst Sander U, Raab S, Richter HG, Sewing S, Sprecher U, Ullmer C, Mattei P. Dehmlow H, et al. Among authors: obst sander u. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4627-32. doi: 10.1016/j.bmcl.2013.06.017. Epub 2013 Jun 19. Bioorg Med Chem Lett. 2013. PMID: 23831134

7

Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors.

Zbinden KG, Obst-Sander U, Hilpert K, Kühne H, Banner DW, Böhm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lavé T. Zbinden KG, et al. Among authors: obst sander u. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5344-52. doi: 10.1016/j.bmcl.2005.04.079. Epub 2005 Oct 4. Bioorg Med Chem Lett. 2005. PMID: 16213138

8

Fluorine interactions at the thrombin active site: protein backbone fragments H-C(alpha)-C=O comprise a favorable C-F environment and interactions of C-F with electrophiles.

Olsen JA, Banner DW, Seiler P, Wagner B, Tschopp T, Obst-Sander U, Kansy M, Müller K, Diederich F. Olsen JA, et al. Chembiochem. 2004 May 3;5(5):666-75. doi: 10.1002/cbic.200300907. Chembiochem. 2004. PMID: 15122639

9

A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions.

Olsen J, Seiler P, Wagner B, Fischer H, Tschopp T, Obst-Sander U, Banner DW, Kansy M, Müller K, Diederich F. Olsen J, et al. Org Biomol Chem. 2004 May 7;2(9):1339-52. doi: 10.1039/b402515f. Epub 2004 Apr 14. Org Biomol Chem. 2004. PMID: 15105924

10

A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions.

Olsen JA, Banner DW, Seiler P, Obst Sander U, D'Arcy A, Stihle M, Müller K, Diederich F. Olsen JA, et al. Angew Chem Int Ed Engl. 2003 Jun 6;42(22):2507-11. doi: 10.1002/anie.200351268. Angew Chem Int Ed Engl. 2003. PMID: 12800172 No abstract available.

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