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Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections.
Carter GP, Chakravorty A, Pham Nguyen TA, Mileto S, Schreiber F, Li L, Howarth P, Clare S, Cunningham B, Sambol SP, Cheknis A, Figueroa I, Johnson S, Gerding D, Rood JI, Dougan G, Lawley TD, Lyras D. Carter GP, et al. Among authors: lyras d. mBio. 2015 Jun 2;6(3):e00551. doi: 10.1128/mBio.00551-15. mBio. 2015. PMID: 26037121 Free PMC article.
Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis.
Huang J, Kelly CP, Bakirtzi K, Villafuerte Gálvez JA, Lyras D, Mileto SJ, Larcombe S, Xu H, Yang X, Shields KS, Zhu W, Zhang Y, Goldsmith JD, Patel IJ, Hansen J, Huang M, Yla-Herttuala S, Moss AC, Paredes-Sabja D, Pothoulakis C, Shah YM, Wang J, Chen X. Huang J, et al. Among authors: lyras d. Nat Microbiol. 2019 Feb;4(2):269-279. doi: 10.1038/s41564-018-0300-x. Epub 2018 Dec 3. Nat Microbiol. 2019. PMID: 30510170 Free PMC article.
Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease.
Mileto SJ, Jardé T, Childress KO, Jensen JL, Rogers AP, Kerr G, Hutton ML, Sheedlo MJ, Bloch SC, Shupe JA, Horvay K, Flores T, Engel R, Wilkins S, McMurrick PJ, Lacy DB, Abud HE, Lyras D. Mileto SJ, et al. Among authors: lyras d. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):8064-8073. doi: 10.1073/pnas.1915255117. Epub 2020 Mar 20. Proc Natl Acad Sci U S A. 2020. PMID: 32198200 Free PMC article.
Human Plasminogen Exacerbates Clostridioides difficile Enteric Disease and Alters the Spore Surface.
Awad MM, Hutton ML, Quek AJ, Klare WP, Mileto SJ, Mackin K, Ly D, Oorschot V, Bosnjak M, Jenkin G, Conroy PJ, West N, Fulcher A, Costin A, Day CJ, Jennings MP, Medcalf RL, Sanderson-Smith M, Cordwell SJ, Law RHP, Whisstock JC, Lyras D. Awad MM, et al. Among authors: lyras d. Gastroenterology. 2020 Oct;159(4):1431-1443.e6. doi: 10.1053/j.gastro.2020.06.032. Epub 2020 Jun 20. Gastroenterology. 2020. PMID: 32574621
The antimicrobial potential of cannabidiol.
Blaskovich MAT, Kavanagh AM, Elliott AG, Zhang B, Ramu S, Amado M, Lowe GJ, Hinton AO, Pham DMT, Zuegg J, Beare N, Quach D, Sharp MD, Pogliano J, Rogers AP, Lyras D, Tan L, West NP, Crawford DW, Peterson ML, Callahan M, Thurn M. Blaskovich MAT, et al. Among authors: lyras d. Commun Biol. 2021 Jan 19;4(1):7. doi: 10.1038/s42003-020-01530-y. Commun Biol. 2021. PMID: 33469147 Free PMC article.
175 results