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GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma.
Gargett T, Ebert LM, Truong NTH, Kollis PM, Sedivakova K, Yu W, Yeo ECF, Wittwer NL, Gliddon BL, Tea MN, Ormsby R, Poonnoose S, Nowicki J, Vittorio O, Ziegler DS, Pitson SM, Brown MP. Gargett T, et al. Among authors: ziegler ds. J Immunother Cancer. 2022 Sep;10(9):e005187. doi: 10.1136/jitc-2022-005187. J Immunother Cancer. 2022. PMID: 36167468 Free PMC article.
Frontiers in the treatment of glioblastoma: Past, present and emerging.
Janjua TI, Rewatkar P, Ahmed-Cox A, Saeed I, Mansfeld FM, Kulshreshtha R, Kumeria T, Ziegler DS, Kavallaris M, Mazzieri R, Popat A. Janjua TI, et al. Among authors: ziegler ds. Adv Drug Deliv Rev. 2021 Apr;171:108-138. doi: 10.1016/j.addr.2021.01.012. Epub 2021 Jan 21. Adv Drug Deliv Rev. 2021. PMID: 33486006 Review.
Doxorubicin-Loaded Gold Nanoarchitectures as a Therapeutic Strategy against Diffuse Intrinsic Pontine Glioma.
Ung C, Tsoli M, Liu J, Cassano D, Pocoví-Martínez S, Upton DH, Ehteda A, Mansfeld FM, Failes TW, Farfalla A, Katsinas C, Kavallaris M, Arndt GM, Vittorio O, Cirillo G, Voliani V, Ziegler DS. Ung C, et al. Among authors: ziegler ds. Cancers (Basel). 2021 Mar 13;13(6):1278. doi: 10.3390/cancers13061278. Cancers (Basel). 2021. PMID: 33805713 Free PMC article.
Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG.
Ehteda A, Simon S, Franshaw L, Giorgi FM, Liu J, Joshi S, Rouaen JRC, Pang CNI, Pandher R, Mayoh C, Tang Y, Khan A, Ung C, Tolhurst O, Kankean A, Hayden E, Lehmann R, Shen S, Gopalakrishnan A, Trebilcock P, Gurova K, Gudkov AV, Norris MD, Haber M, Vittorio O, Tsoli M, Ziegler DS. Ehteda A, et al. Among authors: ziegler ds. Cell Rep. 2021 Apr 13;35(2):108994. doi: 10.1016/j.celrep.2021.108994. Cell Rep. 2021. PMID: 33852836 Free article.
Early-phenotype CAR-T cells for the treatment of pediatric cancers.
Meyran D, Terry RL, Zhu JJ, Haber M, Ziegler DS, Ekert PG, Trapani JA, Darcy PK, Neeson PJ. Meyran D, et al. Among authors: ziegler ds. Ann Oncol. 2021 Nov;32(11):1366-1380. doi: 10.1016/j.annonc.2021.07.018. Epub 2021 Aug 8. Ann Oncol. 2021. PMID: 34375680 Free article. Review.
A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer.
Mayoh C, Gifford AJ, Terry R, Lau LMS, Wong M, Rao P, Shai-Hee T, Saletta F, Khuong-Quang DA, Qin V, Mateos MK, Meyran D, Miller KE, Yuksel A, Mould EVA, Bowen-James R, Govender D, Senapati A, Zhukova N, Omer N, Dholaria H, Alvaro F, Tapp H, Diamond Y, Pozza LD, Moore AS, Nicholls W, Gottardo NG, McCowage G, Hansford JR, Khaw SL, Wood PJ, Catchpoole D, Cottrell CE, Mardis ER, Marshall GM, Tyrrell V, Haber M, Ziegler DS, Vittorio O, Trapani JA, Cowley MJ, Neeson PJ, Ekert PG. Mayoh C, et al. Among authors: ziegler ds. Genome Med. 2023 Apr 3;15(1):20. doi: 10.1186/s13073-023-01170-x. Genome Med. 2023. PMID: 37013636 Free PMC article.
Copper chelation suppresses epithelial-mesenchymal transition by inhibition of canonical and non-canonical TGF-β signaling pathways in cancer.
Poursani EM, Mercatelli D, Raninga P, Bell JL, Saletta F, Kohane FV, Neumann DP, Zheng Y, Rouaen JRC, Jue TR, Michniewicz FT, Schadel P, Kasiou E, Tsoli M, Cirillo G, Waters S, Shai-Hee T, Cazzoli R, Brettle M, Slapetova I, Kasherman M, Whan R, Souza-Fonseca-Guimaraes F, Vahdat L, Ziegler D, Lock JG, Giorgi FM, Khanna K, Vittorio O. Poursani EM, et al. Cell Biosci. 2023 Jul 21;13(1):132. doi: 10.1186/s13578-023-01083-7. Cell Biosci. 2023. PMID: 37480151 Free PMC article.
166 results