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Quinazoline-based human phosphodiesterase 5 inhibitors exhibited a selective vasorelaxant effect on rat isolated pulmonary arteries involving NO-sGC-cGMP pathway and calcium inhibitory effects.
Vascul Pharmacol. 2022 Dec;147:107111. doi: 10.1016/j.vph.2022.107111. Epub 2022 Sep 24.
Vascul Pharmacol. 2022.
PMID: 36162651
The new quinazoline derivative (N2-methyl-N4-[(thiophen-2-yl)methyl]quinazoline-2,4-diamine) vasodilates isolated mesenteric arteries through endothelium-independent mechanisms and has acute hypotensive effects in Wistar rats.
Chatturong U, Chootip K, Martin H, Tournier-Nappey M, Ingkaninan K, Temkitthawon P, Sermsenaphorn S, Somarin T, Konsue A, Gleeson MP, Totoson P, Demougeot C.
Chatturong U, et al. Among authors: somarin t.
Eur J Pharmacol. 2023 Aug 15;953:175829. doi: 10.1016/j.ejphar.2023.175829. Epub 2023 Jun 10.
Eur J Pharmacol. 2023.
PMID: 37307938
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