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Quinazoline-based human phosphodiesterase 5 inhibitors exhibited a selective vasorelaxant effect on rat isolated pulmonary arteries involving NO-sGC-cGMP pathway and calcium inhibitory effects.
Chatturong U, Martin H, Totoson P, Ingkaninan K, Temkitthawon P, Sermsenaphorn S, Somarin T, Konsue A, Gleeson MP, Demougeot C, Chootip K. Chatturong U, et al. Among authors: gleeson mp. Vascul Pharmacol. 2022 Dec;147:107111. doi: 10.1016/j.vph.2022.107111. Epub 2022 Sep 24. Vascul Pharmacol. 2022. PMID: 36162651
Elucidation of Vasodilation Response and Structure Activity Relationships of N²,N⁴-Disubstituted Quinazoline 2,4-Diamines in a Rat Pulmonary Artery Model.
Paracha TU, Pobsuk N, Salaloy N, Suphakun P, Pekthong D, Hannongbua S, Choowongkomon K, Khorana N, Temkitthawon P, Ingkaninan K, Gleeson MP, Chootip K. Paracha TU, et al. Among authors: gleeson mp. Molecules. 2019 Jan 14;24(2):281. doi: 10.3390/molecules24020281. Molecules. 2019. PMID: 30646523 Free PMC article.
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