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Investigation of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of the HIV-1 Maturation Inhibitor GSK3640254 Using an Intravenous Microtracer Combined with EnteroTracker for Biliary Sampling.
Wen B, Zhang Y, Young GC, Kenworthy D, Pereira A, Pirhalla J, Doyle J, Jordon B, Zhan J, Johnson M. Wen B, et al. Among authors: kenworthy d. Drug Metab Dispos. 2022 Nov;50(11):1442-1453. doi: 10.1124/dmd.122.000955. Epub 2022 Sep 24. Drug Metab Dispos. 2022. PMID: 36153007 Clinical Trial.
An Innovative Approach to Characterize Clinical ADME and Pharmacokinetics of the Inhaled Drug Nemiralisib Using an Intravenous Microtracer Combined with an Inhaled Dose and an Oral Radiolabel Dose in Healthy Male Subjects.
Harrell AW, Wilson R, Man YL, Riddell K, Jarvis E, Young G, Chambers R, Crossman L, Georgiou A, Pereira A, Kenworthy D, Beaumont C, Marotti M, Wilkes D, Hessel EM, Fahy WA. Harrell AW, et al. Among authors: kenworthy d. Drug Metab Dispos. 2019 Dec;47(12):1457-1468. doi: 10.1124/dmd.119.088344. Epub 2019 Oct 24. Drug Metab Dispos. 2019. PMID: 31649125 Clinical Trial.
Pharmacokinetics and ADME Characterization of Intravenous and Oral [14C]-Linerixibat in Healthy Male Volunteers.
Zamek-Gliszczynski MJ, Kenworthy D, Bershas DA, Sanghvi M, Pereira AI, Mudunuru J, Crossman L, Pirhalla JL, Thorpe KM, Dennison JMTJ, McLaughlin MM, Allinder M, Swift B, O'Connor-Semmes RL, Young GC. Zamek-Gliszczynski MJ, et al. Among authors: kenworthy d. Drug Metab Dispos. 2021 Dec;49(12):1109-1117. doi: 10.1124/dmd.121.000595. Epub 2021 Oct 8. Drug Metab Dispos. 2021. PMID: 34625435 Clinical Trial.
Meeting report: oligonucleotide ADME workshop.
Hood S, Kenworthy D, Christensen JK. Hood S, et al. Among authors: kenworthy d. Xenobiotica. 2022 Aug;52(8):957-961. doi: 10.1080/00498254.2022.2115428. Epub 2022 Sep 12. Xenobiotica. 2022. PMID: 36093882