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Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
Wilson JE, Petrucelli AS, Chen L, Koblansky AA, Truax AD, Oyama Y, Rogers AB, Brickey WJ, Wang Y, Schneider M, Mühlbauer M, Chou WC, Barker BR, Jobin C, Allbritton NL, Ramsden DA, Davis BK, Ting JP. Wilson JE, et al. Among authors: chou wc. Nat Med. 2015 Aug;21(8):906-13. doi: 10.1038/nm.3908. Epub 2015 Jun 24. Nat Med. 2015. PMID: 26107252 Free PMC article.
NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth.
Chen L, Wilson JE, Koenigsknecht MJ, Chou WC, Montgomery SA, Truax AD, Brickey WJ, Packey CD, Maharshak N, Matsushima GK, Plevy SE, Young VB, Sartor RB, Ting JP. Chen L, et al. Among authors: chou wc. Nat Immunol. 2017 May;18(5):541-551. doi: 10.1038/ni.3690. Epub 2017 Mar 13. Nat Immunol. 2017. PMID: 28288099 Free PMC article.
Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation.
Zhang S, Takaku M, Zou L, Gu AD, Chou WC, Zhang G, Wu B, Kong Q, Thomas SY, Serody JS, Chen X, Xu X, Wade PA, Cook DN, Ting JPY, Wan YY. Zhang S, et al. Among authors: chou wc. Nature. 2017 Nov 2;551(7678):105-109. doi: 10.1038/nature24283. Epub 2017 Oct 25. Nature. 2017. PMID: 29072299 Free PMC article.
The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis.
Truax AD, Chen L, Tam JW, Cheng N, Guo H, Koblansky AA, Chou WC, Wilson JE, Brickey WJ, Petrucelli A, Liu R, Cooper DE, Koenigsknecht MJ, Young VB, Netea MG, Stienstra R, Sartor RB, Montgomery SA, Coleman RA, Ting JP. Truax AD, et al. Among authors: chou wc. Cell Host Microbe. 2018 Sep 12;24(3):364-378.e6. doi: 10.1016/j.chom.2018.08.009. Cell Host Microbe. 2018. PMID: 30212649 Free PMC article.
Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites.
Guo H, Chou WC, Lai Y, Liang K, Tam JW, Brickey WJ, Chen L, Montgomery ND, Li X, Bohannon LM, Sung AD, Chao NJ, Peled JU, Gomes ALC, van den Brink MRM, French MJ, Macintyre AN, Sempowski GD, Tan X, Sartor RB, Lu K, Ting JPY. Guo H, et al. Among authors: chou wc. Science. 2020 Oct 30;370(6516):eaay9097. doi: 10.1126/science.aay9097. Science. 2020. PMID: 33122357 Free PMC article.
AIM2 in regulatory T cells restrains autoimmune diseases.
Chou WC, Guo Z, Guo H, Chen L, Zhang G, Liang K, Xie L, Tan X, Gibson SA, Rampanelli E, Wang Y, Montgomery SA, Brickey WJ, Deng M, Freeman L, Zhang S, Su MA, Chen X, Wan YY, Ting JP. Chou WC, et al. Nature. 2021 Mar;591(7849):300-305. doi: 10.1038/s41586-021-03231-w. Epub 2021 Jan 27. Nature. 2021. PMID: 33505023 Free PMC article.
669 results