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A new Kunitz trypsin inhibitor from Erythrina poeppigiana exhibits antimicrobial and antibiofilm properties against bacteria.
Alencar de Barros KM, Sardi JCO, Maria-Neto S, Macedo AJ, Ramalho SR, Lourenço de Oliveira DG, Pontes GS, Weber SS, Ramalho de Oliveira CF, Macedo MLR. Alencar de Barros KM, et al. Among authors: ramalho sr. Biomed Pharmacother. 2021 Dec;144:112198. doi: 10.1016/j.biopha.2021.112198. Epub 2021 Oct 15. Biomed Pharmacother. 2021. PMID: 34656058 Free article.
The synthetic antimicrobial peptide IKR18 displays anti-infectious properties in Galleria mellonella in vivo model.
Ramalho SR, de Cássia Orlandi Sardi J, Júnior EC, Marchetto R, Wender H, Vargas LFP, de Miranda A, Almeida CV, de Oliveira Almeida LH, de Oliveira CFR, Macedo MLR. Ramalho SR, et al. Biochim Biophys Acta Gen Subj. 2022 Dec;1866(12):130244. doi: 10.1016/j.bbagen.2022.130244. Epub 2022 Sep 23. Biochim Biophys Acta Gen Subj. 2022. PMID: 36162730
A potent candicidal peptide designed based on an encrypted peptide from a proteinase inhibitor.
Almeida LHO, Ramalho SR, Almeida CV, Gutierrez CO, Sardi JCO, Miranda A, Oliveira RA, Rezende SB, Crusca E, Franco OL, Oliveira CFR, Cardoso MH, Macedo MLR. Almeida LHO, et al. Among authors: ramalho sr. Biochim Biophys Acta Gen Subj. 2024 May;1868(5):130583. doi: 10.1016/j.bbagen.2024.130583. Epub 2024 Feb 13. Biochim Biophys Acta Gen Subj. 2024. PMID: 38360076