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Vivaxin genes encode highly immunogenic, non-variant antigens on the Trypanosoma vivax cell-surface.
Romero-Ramirez A, Casas-Sánchez A, Autheman D, Duffy CW, Brandt C, Clare S, Harcourt K, André MR, de Almeida Castilho Neto KJG, Teixeira MMG, Machado RZ, Coombes J, Flynn RJ, Wright GJ, Jackson AP. Romero-Ramirez A, et al. Among authors: harcourt k. PLoS Negl Trop Dis. 2022 Sep 21;16(9):e0010791. doi: 10.1371/journal.pntd.0010791. eCollection 2022 Sep. PLoS Negl Trop Dis. 2022. PMID: 36129968 Free PMC article.
Signatures of adaptation in human invasive Salmonella Typhimurium ST313 populations from sub-Saharan Africa.
Okoro CK, Barquist L, Connor TR, Harris SR, Clare S, Stevens MP, Arends MJ, Hale C, Kane L, Pickard DJ, Hill J, Harcourt K, Parkhill J, Dougan G, Kingsley RA. Okoro CK, et al. Among authors: harcourt k. PLoS Negl Trop Dis. 2015 Mar 24;9(3):e0003611. doi: 10.1371/journal.pntd.0003611. eCollection 2015 Mar. PLoS Negl Trop Dis. 2015. PMID: 25803844 Free PMC article.
Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection.
Gimeno Brias S, Marsden M, Forbester J, Clement M, Brandt C, Harcourt K, Kane L, Chapman L, Clare S, Humphreys IR. Gimeno Brias S, et al. Among authors: harcourt k. PLoS One. 2018 May 16;13(5):e0197596. doi: 10.1371/journal.pone.0197596. eCollection 2018. PLoS One. 2018. PMID: 29768502 Free PMC article.
FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele.
Ballesteros Reviriego C, Clare S, Arends MJ, Cambridge EL, Swiatkowska A, Caetano S, Abu-Helil B, Kane L, Harcourt K, Goulding DA, Gleeson D, Ryder E, Doe B, White JK, van der Weyden L, Dougan G, Adams DJ, Speak AO. Ballesteros Reviriego C, et al. Among authors: harcourt k. PLoS One. 2019 Mar 6;14(3):e0212481. doi: 10.1371/journal.pone.0212481. eCollection 2019. PLoS One. 2019. PMID: 30840666 Free PMC article.
Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivo.
Awuah-Mensah G, McDonald J, Steketee PC, Autheman D, Whipple S, D'Archivio S, Brandt C, Clare S, Harcourt K, Wright GJ, Morrison LJ, Gadelha C, Wickstead B. Awuah-Mensah G, et al. Among authors: harcourt k. PLoS Pathog. 2021 Jan 22;17(1):e1009224. doi: 10.1371/journal.ppat.1009224. eCollection 2021 Jan. PLoS Pathog. 2021. PMID: 33481935 Free PMC article.
An invariant Trypanosoma vivax vaccine antigen induces protective immunity.
Autheman D, Crosnier C, Clare S, Goulding DA, Brandt C, Harcourt K, Tolley C, Galaway F, Khushu M, Ong H, Romero-Ramirez A, Duffy CW, Jackson AP, Wright GJ. Autheman D, et al. Among authors: harcourt k. Nature. 2021 Jul;595(7865):96-100. doi: 10.1038/s41586-021-03597-x. Epub 2021 May 26. Nature. 2021. PMID: 34040257
59 results