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Page 1
Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ.
Bubenik M, Mader P, Mochirian P, Vallée F, Clark J, Truchon JF, Perryman AL, Pau V, Kurinov I, Zahn KE, Leclaire ME, Papp R, Mathieu MC, Hamel M, Duffy NM, Godbout C, Casas-Selves M, Falgueyret JP, Baruah PS, Nicolas O, Stocco R, Poirier H, Martino G, Fortin AB, Roulston A, Chefson A, Dorich S, St-Onge M, Patel P, Pellerin C, Ciblat S, Pinter T, Barabé F, El Bakkouri M, Parikh P, Gervais C, Sfeir A, Mamane Y, Morris SJ, Black WC, Sicheri F, Gallant M. Bubenik M, et al. Among authors: poirier h. J Med Chem. 2022 Oct 13;65(19):13198-13215. doi: 10.1021/acs.jmedchem.2c00998. Epub 2022 Sep 20. J Med Chem. 2022. PMID: 36126059 Free PMC article.
Novel non-nucleobase inhibitors of Staphylococcus aureus DNA polymerase IIIC.
Rose Y, Ciblat S, Reddy R, Belley AC, Dietrich E, Lehoux D, McKay GA, Poirier H, Far AR, Delorme D. Rose Y, et al. Among authors: poirier h. Bioorg Med Chem Lett. 2006 Feb 15;16(4):891-6. doi: 10.1016/j.bmcl.2005.11.009. Epub 2005 Nov 17. Bioorg Med Chem Lett. 2006. PMID: 16298129
MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis.
Clark P, Rowland SE, Denis D, Mathieu MC, Stocco R, Poirier H, Burch J, Han Y, Audoly L, Therien AG, Xu D. Clark P, et al. Among authors: poirier h. J Pharmacol Exp Ther. 2008 May;325(2):425-34. doi: 10.1124/jpet.107.134510. Epub 2008 Feb 20. J Pharmacol Exp Ther. 2008. PMID: 18287210
Linking bisphosphonates to the free amino groups in fluoroquinolones: preparation of osteotropic prodrugs for the prevention of osteomyelitis.
Houghton TJ, Tanaka KS, Kang T, Dietrich E, Lafontaine Y, Delorme D, Ferreira SS, Viens F, Arhin FF, Sarmiento I, Lehoux D, Fadhil I, Laquerre K, Liu J, Ostiguy V, Poirier H, Moeck G, Parr TR Jr, Far AR. Houghton TJ, et al. Among authors: poirier h. J Med Chem. 2008 Nov 13;51(21):6955-69. doi: 10.1021/jm801007z. Epub 2008 Oct 4. J Med Chem. 2008. PMID: 18834106
Bisphosphonated fluoroquinolone esters as osteotropic prodrugs for the prevention of osteomyelitis.
Tanaka KS, Houghton TJ, Kang T, Dietrich E, Delorme D, Ferreira SS, Caron L, Viens F, Arhin FF, Sarmiento I, Lehoux D, Fadhil I, Laquerre K, Liu J, Ostiguy V, Poirier H, Moeck G, Parr TR Jr, Rafai Far A. Tanaka KS, et al. Among authors: poirier h. Bioorg Med Chem. 2008 Oct 15;16(20):9217-29. doi: 10.1016/j.bmc.2008.09.010. Epub 2008 Sep 9. Bioorg Med Chem. 2008. PMID: 18815051
Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1.
Wu TY, Juteau H, Ducharme Y, Friesen RW, Guiral S, Dufresne L, Poirier H, Salem M, Riendeau D, Mancini J, Brideau C. Wu TY, et al. Among authors: poirier h. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6978-82. doi: 10.1016/j.bmcl.2010.09.129. Epub 2010 Oct 19. Bioorg Med Chem Lett. 2010. PMID: 20965723
A strategy to reduce biliary clearance in early drug discovery.
Rioux N, Bellavance E, Poirier H, Dupuis M, Garneau M, Ribadeneira MD, Duan J. Rioux N, et al. Among authors: poirier h. J Pharmacol Toxicol Methods. 2013 Nov-Dec;68(3):346-8. doi: 10.1016/j.vascn.2013.03.003. Epub 2013 Mar 19. J Pharmacol Toxicol Methods. 2013. PMID: 23518065
Association of ventilator type with hospital mortality in critically ill patients with SARS-CoV2 infection: a prospective study.
Ferré A, Marquion F, Delord M, Gros A, Lacave G, Laurent V, Merceron S, Paul M, Simon C, Troché G, Charbonnel C, Marque-Juillet S, Bruneel F, Legriel S; RESPI-COVID19 Study Group. Ferré A, et al. Ann Intensive Care. 2022 Feb 8;12(1):10. doi: 10.1186/s13613-022-00981-2. Ann Intensive Care. 2022. PMID: 35133543 Free PMC article.
45 results