Hurley K - Search Results

1

Pathogenic and Commensal Gut Bacteria Harboring Glycerol/Diol Dehydratase Metabolize Glycerol and Produce DNA-Reactive Acrolein.

Ramirez Garcia A, Hurley K, Marastoni G, Diard M, Hofer S, Greppi A, Hardt WD, Lacroix C, Sturla SJ, Schwab C. Ramirez Garcia A, et al. Among authors: hurley k. Chem Res Toxicol. 2022 Oct 17;35(10):1840-1850. doi: 10.1021/acs.chemrestox.2c00137. Epub 2022 Sep 18. Chem Res Toxicol. 2022. PMID: 36116084 Free PMC article.

2

Impact of manipulation of glycerol/diol dehydratase activity on intestinal microbiota ecology and metabolism.

Ramirez Garcia A, Zhang J, Greppi A, Constancias F, Wortmann E, Wandres M, Hurley K, Pascual-García A, Ruscheweyh HJ, Sturla SJ, Lacroix C, Schwab C. Ramirez Garcia A, et al. Among authors: hurley k. Environ Microbiol. 2021 Mar;23(3):1765-1779. doi: 10.1111/1462-2920.15431. Epub 2021 Mar 15. Environ Microbiol. 2021. PMID: 33587772

3

Gyramides prevent bacterial growth by inhibiting DNA gyrase and altering chromosome topology.

Rajendram M, Hurley KA, Foss MH, Thornton KM, Moore JT, Shaw JT, Weibel DB. Rajendram M, et al. ACS Chem Biol. 2014 Jun 20;9(6):1312-9. doi: 10.1021/cb500154m. Epub 2014 Apr 22. ACS Chem Biol. 2014. PMID: 24712739 Free PMC article.

4

N-Benzyl-3-sulfonamidopyrrolidines are a New Class of Bacterial DNA Gyrase Inhibitors.

Foss MH, Hurley KA, Sorto N, Lackner LL, Thornton KM, Shaw JT, Weibel DB. Foss MH, et al. ACS Med Chem Lett. 2011 Apr 14;2(4):289-292. doi: 10.1021/ml1002822. ACS Med Chem Lett. 2011. PMID: 21552338 Free PMC article.

5

Targeting the Bacterial Division Protein FtsZ.

Hurley KA, Santos TM, Nepomuceno GM, Huynh V, Shaw JT, Weibel DB. Hurley KA, et al. J Med Chem. 2016 Aug 11;59(15):6975-98. doi: 10.1021/acs.jmedchem.5b01098. Epub 2016 Mar 10. J Med Chem. 2016. PMID: 26756351 Review.

6

5-Alkyloxytryptamines are membrane-targeting, broad-spectrum antibiotics.

Faulkner KC, Hurley KA, Weibel DB. Faulkner KC, et al. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5539-5544. doi: 10.1016/j.bmcl.2016.10.004. Epub 2016 Oct 5. Bioorg Med Chem Lett. 2016. PMID: 27765507 Free PMC article.

7

Targeting quinolone- and aminocoumarin-resistant bacteria with new gyramide analogs that inhibit DNA gyrase.

Hurley KA, Santos TMA, Fensterwald MR, Rajendran M, Moore JT, Balmond EI, Blahnik BJ, Faulkner KC, Foss MH, Heinrich VA, Lammers MG, Moore LC, Reynolds GD, Shearn-Nance GP, Stearns BA, Yao ZW, Shaw JT, Weibel DB. Hurley KA, et al. Medchemcomm. 2017;8(5):942-951. doi: 10.1039/C7MD00012J. Epub 2017 Feb 27. Medchemcomm. 2017. PMID: 30034678 Free PMC article.

8

Membrane-Targeting DCAP Analogues with Broad-Spectrum Antibiotic Activity against Pathogenic Bacteria.

Hurley KA, Heinrich VA, Hershfield JR, Demons ST, Weibel DB. Hurley KA, et al. ACS Med Chem Lett. 2015 Mar 1;6(4):466-71. doi: 10.1021/acsmedchemlett.5b00024. eCollection 2015 Apr 9. ACS Med Chem Lett. 2015. PMID: 25941556 Free PMC article.

9

Synthesis of a γ-lactam library via formal cycloaddition of imines and substituted succinic anhydrides.

Tan DQ, Atherton AL, Smith AJ, Soldi C, Hurley KA, Fettinger JC, Shaw JT. Tan DQ, et al. ACS Comb Sci. 2012 Mar 12;14(3):218-23. doi: 10.1021/co2001873. Epub 2012 Feb 10. ACS Comb Sci. 2012. PMID: 22225535 Free PMC article.

10

A roadmap to precision treatments for familial pulmonary fibrosis.

Hurley K, Ozaki M, Philippot Q, Galvin L, Crosby D, Kirwan M, Gill DR, Alysandratos KD, Jenkins G, Griese M, Nathan N, Borie R; COST Open-ILD Group Management Committee. Hurley K, et al. EBioMedicine. 2024 May 7;104:105135. doi: 10.1016/j.ebiom.2024.105135. Online ahead of print. EBioMedicine. 2024. PMID: 38718684 Free PMC article. Review.

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