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The coumarin osthole is a non-electrophilic agonist of TRPA1.
Torres KV, Pantke S, Rudolf D, Eberhardt MM, Leffler A. Torres KV, et al. Among authors: leffler a. Neurosci Lett. 2022 Oct 15;789:136878. doi: 10.1016/j.neulet.2022.136878. Epub 2022 Sep 15. Neurosci Lett. 2022. PMID: 36115537
TRPA1 and substance P mediate colitis in mice.
Engel MA, Leffler A, Niedermirtl F, Babes A, Zimmermann K, Filipović MR, Izydorczyk I, Eberhardt M, Kichko TI, Mueller-Tribbensee SM, Khalil M, Siklosi N, Nau C, Ivanović-Burmazović I, Neuhuber WL, Becker C, Neurath MF, Reeh PW. Engel MA, et al. Among authors: leffler a. Gastroenterology. 2011 Oct;141(4):1346-58. doi: 10.1053/j.gastro.2011.07.002. Epub 2011 Jul 18. Gastroenterology. 2011. PMID: 21763243
Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy.
Bierhaus A, Fleming T, Stoyanov S, Leffler A, Babes A, Neacsu C, Sauer SK, Eberhardt M, Schnölzer M, Lasitschka F, Neuhuber WL, Kichko TI, Konrade I, Elvert R, Mier W, Pirags V, Lukic IK, Morcos M, Dehmer T, Rabbani N, Thornalley PJ, Edelstein D, Nau C, Forbes J, Humpert PM, Schwaninger M, Ziegler D, Stern DM, Cooper ME, Haberkorn U, Brownlee M, Reeh PW, Nawroth PP. Bierhaus A, et al. Among authors: leffler a. Nat Med. 2012 Jun;18(6):926-33. doi: 10.1038/nm.2750. Nat Med. 2012. PMID: 22581285
The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6.
de la Roche J, Eberhardt MJ, Klinger AB, Stanslowsky N, Wegner F, Koppert W, Reeh PW, Lampert A, Fischer MJ, Leffler A. de la Roche J, et al. Among authors: leffler a. J Biol Chem. 2013 Jul 12;288(28):20280-92. doi: 10.1074/jbc.M113.479337. Epub 2013 May 24. J Biol Chem. 2013. PMID: 23709225 Free PMC article.
Amplified cold transduction in native nociceptors by M-channel inhibition.
Vetter I, Hein A, Sattler S, Hessler S, Touska F, Bressan E, Parra A, Hager U, Leffler A, Boukalova S, Nissen M, Lewis RJ, Belmonte C, Alzheimer C, Huth T, Vlachova V, Reeh PW, Zimmermann K. Vetter I, et al. Among authors: leffler a. J Neurosci. 2013 Oct 16;33(42):16627-41. doi: 10.1523/JNEUROSCI.1473-13.2013. J Neurosci. 2013. PMID: 24133266 Free PMC article.
H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway.
Eberhardt M, Dux M, Namer B, Miljkovic J, Cordasic N, Will C, Kichko TI, de la Roche J, Fischer M, Suárez SA, Bikiel D, Dorsch K, Leffler A, Babes A, Lampert A, Lennerz JK, Jacobi J, Martí MA, Doctorovich F, Högestätt ED, Zygmunt PM, Ivanovic-Burmazovic I, Messlinger K, Reeh P, Filipovic MR. Eberhardt M, et al. Among authors: leffler a. Nat Commun. 2014 Jul 15;5:4381. doi: 10.1038/ncomms5381. Nat Commun. 2014. PMID: 25023795 Free PMC article.
184 results