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Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection.
Ang CW, Lee BM, Jackson CJ, Wang Y, Franzblau SG, Francisco AF, Kelly JM, Bernhardt PV, Tan L, West NP, Sykes ML, Hinton AO, Bolisetti R, Avery VM, Cooper MA, Blaskovich MAT. Ang CW, et al. Among authors: bernhardt pv. J Med Chem. 2022 Oct 13;65(19):13125-13142. doi: 10.1021/acs.jmedchem.2c00972. Epub 2022 Sep 16. J Med Chem. 2022. PMID: 36111399
2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: structural design, synthesis and pharmacological evaluation.
Cardoso MV, de Siqueira LR, da Silva EB, Costa LB, Hernandes MZ, Rabello MM, Ferreira RS, da Cruz LF, Moreira DR, Pereira VR, de Castro MC, Bernhardt PV, Leite AC. Cardoso MV, et al. Among authors: bernhardt pv. Eur J Med Chem. 2014 Oct 30;86:48-59. doi: 10.1016/j.ejmech.2014.08.012. Epub 2014 Aug 6. Eur J Med Chem. 2014. PMID: 25147146
The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement.
Houston SD, Fahrenhorst-Jones T, Xing H, Chalmers BA, Sykes ML, Stok JE, Farfan Soto C, Burns JM, Bernhardt PV, De Voss JJ, Boyle GM, Smith MT, Tsanaktsidis J, Savage GP, Avery VM, Williams CM. Houston SD, et al. Among authors: bernhardt pv. Org Biomol Chem. 2019 Jul 17;17(28):6790-6798. doi: 10.1039/c9ob01238a. Org Biomol Chem. 2019. PMID: 31241113
Synthesis of steroidal inhibitors for Mycobacterium tuberculosis.
Churchman LR, Beckett JR, Tan L, Woods K, Doherty DZ, Ghith A, Bernhardt PV, Bell SG, West NP, De Voss JJ. Churchman LR, et al. Among authors: bernhardt pv. J Steroid Biochem Mol Biol. 2024 May;239:106479. doi: 10.1016/j.jsbmb.2024.106479. Epub 2024 Feb 10. J Steroid Biochem Mol Biol. 2024. PMID: 38346478
Synthetic and natural products as iron chelators.
Sharpe PC, Richardson DR, Kalinowski DS, Bernhardt PV. Sharpe PC, et al. Among authors: bernhardt pv. Curr Top Med Chem. 2011;11(5):591-607. doi: 10.2174/156802611794785163. Curr Top Med Chem. 2011. PMID: 21189130 Review.
Designing Tailored Thiosemicarbazones with Bespoke Properties: The Styrene Moiety Imparts Potent Activity, Inhibits Heme Center Oxidation, and Results in a Novel "Stealth Zinc(II) Complex".
Dharmasivam M, Kaya B, Wijesinghe T, Gholam Azad M, Gonzálvez MA, Hussaini M, Chekmarev J, Bernhardt PV, Richardson DR. Dharmasivam M, et al. Among authors: bernhardt pv. J Med Chem. 2023 Jan 26;66(2):1426-1453. doi: 10.1021/acs.jmedchem.2c01600. Epub 2023 Jan 17. J Med Chem. 2023. PMID: 36649565
270 results