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Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade.
Ghosh A, Michels J, Mezzadra R, Venkatesh D, Dong L, Gomez R, Samaan F, Ho YJ, Campesato LF, Mangarin L, Fak J, Suek N, Holland A, Liu C, Abu-Akeel M, Bykov Y, Zhong H, Fitzgerald K, Budhu S, Chow A, Zappasodi R, Panageas KS, de Henau O, Ruscetti M, Lowe SW, Merghoub T, Wolchok JD. Ghosh A, et al. Among authors: michels j. J Clin Invest. 2022 Sep 15;132(18):e148141. doi: 10.1172/JCI148141. J Clin Invest. 2022. PMID: 36106631 Free PMC article.
APR-246 increases tumor antigenicity independent of p53.
Michels J, Venkatesh D, Liu C, Budhu S, Zhong H, George MM, Thach D, Yao ZK, Ouerfelli O, Liu H, Stockwell BR, Campesato LF, Zamarin D, Zappasodi R, Wolchok JD, Merghoub T. Michels J, et al. Life Sci Alliance. 2023 Oct 27;7(1):e202301999. doi: 10.26508/lsa.202301999. Print 2024 Jan. Life Sci Alliance. 2023. PMID: 37891002 Free PMC article.
Combined Tumor-Based BRCA1/2 and TP53 Mutation Testing in Ovarian Cancer.
Borcoman E, Santana Dos Santos E, Genestie C, Pautier P, Lacroix L, Caputo SM, Cabaret O, Guillaud-Bataille M, Michels J, Auguste A, Leary A, Rouleau E. Borcoman E, et al. Among authors: michels j. Int J Mol Sci. 2023 Jul 18;24(14):11570. doi: 10.3390/ijms241411570. Int J Mol Sci. 2023. PMID: 37511329 Free PMC article.
Cancer cell-autonomous overactivation of PARP1 compromises immunosurveillance in non-small cell lung cancer.
Juncheng P, Joseph A, Lafarge A, Martins I, Obrist F, Pol J, Saavedra E, Li S, Sauvat A, Cerrato G, Lévesque S, Leduc M, Kepp O, Durand S, Aprahamian F, Nirmalathansan N, Michels J, Kroemer G, Castedo M. Juncheng P, et al. Among authors: michels j. J Immunother Cancer. 2022 Jun;10(6):e004280. doi: 10.1136/jitc-2021-004280. J Immunother Cancer. 2022. PMID: 35772809 Free PMC article.
Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.
Yao Z, Yaeger R, Rodrik-Outmezguine VS, Tao A, Torres NM, Chang MT, Drosten M, Zhao H, Cecchi F, Hembrough T, Michels J, Baumert H, Miles L, Campbell NM, de Stanchina E, Solit DB, Barbacid M, Taylor BS, Rosen N. Yao Z, et al. Among authors: michels j. Nature. 2017 Aug 10;548(7666):234-238. doi: 10.1038/nature23291. Epub 2017 Aug 2. Nature. 2017. PMID: 28783719 Free PMC article.
Renal toxicities associated with pembrolizumab.
Izzedine H, Mathian A, Champiat S, Picard C, Mateus C, Routier E, Varga A, Malka D, Leary A, Michels J, Michot JM, Marabelle A, Lambotte O, Amoura Z, Soria JC, Kaaki S, Quellard N, Goujon JM, Brocheriou I. Izzedine H, et al. Among authors: michels j. Clin Kidney J. 2019 Feb;12(1):81-88. doi: 10.1093/ckj/sfy100. Epub 2018 Nov 9. Clin Kidney J. 2019. PMID: 30746132 Free PMC article.
[New drugs and targeted therapeutic agents in ovarian cancer].
de La Motte Rouge T, Petrella MC, Michels J, Even C, Balleyguier C, Duclos J, Mazeron R, Morice P, Pautier P, Lhommé C. de La Motte Rouge T, et al. Among authors: michels j. Bull Cancer. 2009 Dec;96(12):1215-24. doi: 10.1684/bdc.2009.0988. Bull Cancer. 2009. PMID: 19919916 Free article. Review. French.
Molecular mechanisms of cisplatin resistance.
Galluzzi L, Senovilla L, Vitale I, Michels J, Martins I, Kepp O, Castedo M, Kroemer G. Galluzzi L, et al. Among authors: michels j. Oncogene. 2012 Apr 12;31(15):1869-83. doi: 10.1038/onc.2011.384. Epub 2011 Sep 5. Oncogene. 2012. PMID: 21892204 Review.
Prognostic impact of vitamin B6 metabolism in lung cancer.
Galluzzi L, Vitale I, Senovilla L, Olaussen KA, Pinna G, Eisenberg T, Goubar A, Martins I, Michels J, Kratassiouk G, Carmona-Gutierrez D, Scoazec M, Vacchelli E, Schlemmer F, Kepp O, Shen S, Tailler M, Niso-Santano M, Morselli E, Criollo A, Adjemian S, Jemaà M, Chaba K, Pailleret C, Michaud M, Pietrocola F, Tajeddine N, de La Motte Rouge T, Araujo N, Morozova N, Robert T, Ripoche H, Commo F, Besse B, Validire P, Fouret P, Robin A, Dorvault N, Girard P, Gouy S, Pautier P, Jägemann N, Nickel AC, Marsili S, Paccard C, Servant N, Hupé P, Behrens C, Behnam-Motlagh P, Kohno K, Cremer I, Damotte D, Alifano M, Midttun O, Ueland PM, Lazar V, Dessen P, Zischka H, Chatelut E, Castedo M, Madeo F, Barillot E, Thomale J, Wistuba II, Sautès-Fridman C, Zitvogel L, Soria JC, Harel-Bellan A, Kroemer G. Galluzzi L, et al. Among authors: michels j. Cell Rep. 2012 Aug 30;2(2):257-69. doi: 10.1016/j.celrep.2012.06.017. Epub 2012 Jul 26. Cell Rep. 2012. PMID: 22854025 Free article.
Vitamin B6 metabolism influences the intracellular accumulation of cisplatin.
Galluzzi L, Marsili S, Vitale I, Senovilla L, Michels J, Garcia P, Vacchelli E, Chatelut E, Castedo M, Kroemer G. Galluzzi L, et al. Among authors: michels j. Cell Cycle. 2013 Feb 1;12(3):417-21. doi: 10.4161/cc.23275. Epub 2012 Feb 1. Cell Cycle. 2013. PMID: 23287530 Free PMC article.
283 results