Sykes MJ - Search Results

1

Cinnamaldehyde derivatives act as antimicrobial agents against Acinetobacter baumannii through the inhibition of cell division.

Chai WC, Whittall JJ, Polyak SW, Foo K, Li X, Dutschke CJ, Ogunniyi AD, Ma S, Sykes MJ, Semple SJ, Venter H. Chai WC, et al. Among authors: sykes mj. Front Microbiol. 2022 Aug 29;13:967949. doi: 10.3389/fmicb.2022.967949. eCollection 2022. Front Microbiol. 2022. PMID: 36106080 Free PMC article.

2

In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes.

Bendikov MY, Miners JO, Simpson BS, Elliot DJ, Semple SJ, Claudie DJ, McKinnon RA, Gillam EMJ, Sykes MJ. Bendikov MY, et al. Among authors: sykes mj. Xenobiotica. 2017 Jun;47(6):461-469. doi: 10.1080/00498254.2016.1203041. Epub 2016 Jul 14. Xenobiotica. 2017. PMID: 27412850

3

Design and synthesis of novel 4-substituted quinazoline-2-carboxamide derivatives targeting AcrB to reverse the bacterial multidrug resistance.

Gu X, Pisoni LA, Wang Y, Song D, Sykes MJ, Qin Y, Semple SJ, Polyak SW, Venter H, Ma S. Gu X, et al. Among authors: sykes mj. Bioorg Chem. 2020 Dec;105:104394. doi: 10.1016/j.bioorg.2020.104394. Epub 2020 Oct 21. Bioorg Chem. 2020. PMID: 33120321

4

Design and structural optimization of novel 2H-benzo[h]chromene derivatives that target AcrB and reverse bacterial multidrug resistance.

Wang Y, Alenazy R, Gu X, Polyak SW, Zhang P, Sykes MJ, Zhang N, Venter H, Ma S. Wang Y, et al. Among authors: sykes mj. Eur J Med Chem. 2021 Mar 5;213:113049. doi: 10.1016/j.ejmech.2020.113049. Epub 2020 Nov 27. Eur J Med Chem. 2021. PMID: 33279291

5

Combined Structure- and Ligand-Based Approach for the Identification of Inhibitors of AcrAB-TolC in Escherichia coli.

Pisoni LA, Semple SJ, Liu S, Sykes MJ, Venter H. Pisoni LA, et al. Among authors: sykes mj. ACS Infect Dis. 2023 Dec 8;9(12):2504-2522. doi: 10.1021/acsinfecdis.3c00350. Epub 2023 Oct 27. ACS Infect Dis. 2023. PMID: 37888944

6

Discovery of CDK5 Inhibitors through Structure-Guided Approach.

Khair NZ, Lenjisa JL, Tadesse S, Kumarasiri M, Basnet SKC, Mekonnen LB, Li M, Diab S, Sykes MJ, Albrecht H, Milne R, Wang S. Khair NZ, et al. Among authors: sykes mj. ACS Med Chem Lett. 2019 Mar 20;10(5):786-791. doi: 10.1021/acsmedchemlett.9b00029. eCollection 2019 May 9. ACS Med Chem Lett. 2019. PMID: 31098000 Free PMC article.

7

Therapeutic Potential of a Novel Vitamin D₃ Oxime Analogue, VD1-6, with CYP24A1 Enzyme Inhibitory Activity and Negligible Vitamin D Receptor Binding.

Alshabrawy AK, Cui Y, Sylvester C, Yang D, Petito ES, Barratt KR, Sawyer RK, Heatlie JK, Polara R, Sykes MJ, Atkins GJ, Hickey SM, Wiese MD, Stringer AM, Liu Z, Anderson PH. Alshabrawy AK, et al. Among authors: sykes mj. Biomolecules. 2022 Jul 8;12(7):960. doi: 10.3390/biom12070960. Biomolecules. 2022. PMID: 35883516 Free PMC article.

8

Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation.

Diab S, Teo T, Kumarasiri M, Li P, Yu M, Lam F, Basnet SK, Sykes MJ, Albrecht H, Milne R, Wang S. Diab S, et al. Among authors: sykes mj. ChemMedChem. 2014 May;9(5):962-72. doi: 10.1002/cmdc.201300552. Epub 2014 Feb 12. ChemMedChem. 2014. PMID: 24677692

9

Discovery of N,4-Di(1H-pyrazol-4-yl)pyrimidin-2-amine-Derived CDK2 Inhibitors as Potential Anticancer Agents: Design, Synthesis, and Evaluation.

Fanta BS, Lenjisa J, Teo T, Kou L, Mekonnen L, Yang Y, Basnet SKC, Hassankhani R, Sykes MJ, Yu M, Wang S. Fanta BS, et al. Among authors: sykes mj. Molecules. 2023 Mar 25;28(7):2951. doi: 10.3390/molecules28072951. Molecules. 2023. PMID: 37049714 Free PMC article.

10

Molecular Modeling Approaches for the Prediction of Selected Pharmacokinetic Properties.

Petito ES, Foster DJR, Ward MB, Sykes MJ. Petito ES, et al. Among authors: sykes mj. Curr Top Med Chem. 2018;18(26):2230-2238. doi: 10.2174/1568026619666181220105726. Curr Top Med Chem. 2018. PMID: 30569859 Review.

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