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Oral Exposure to Lead Acetate for 28 Days Reduces the Number of Neural Progenitor Cells but Increases the Number and Synaptic Plasticity of Newborn Granule Cells in Adult Hippocampal Neurogenesis of Young-Adult Rats.
Maeda N, Shimizu S, Takahashi Y, Kubota R, Uomoto S, Takesue K, Takashima K, Okano H, Ojiro R, Ozawa S, Tang Q, Jin M, Ikarashi Y, Yoshida T, Shibutani M. Maeda N, et al. Among authors: okano h. Neurotox Res. 2022 Dec;40(6):2203-2220. doi: 10.1007/s12640-022-00577-5. Epub 2022 Sep 13. Neurotox Res. 2022. PMID: 36098941
Developmental exposure to diacetoxyscirpenol reversibly disrupts hippocampal neurogenesis by inducing oxidative cellular injury and suppressed differentiation of granule cell lineages in mice.
Nakajima K, Ito Y, Kikuchi S, Okano H, Takashima K, Woo GH, Yoshida T, Yoshinari T, Sugita-Konishi Y, Shibutani M. Nakajima K, et al. Among authors: okano h. Food Chem Toxicol. 2020 Feb;136:111046. doi: 10.1016/j.fct.2019.111046. Epub 2019 Dec 10. Food Chem Toxicol. 2020. PMID: 31836554 Free article.
Downregulation of low-density lipoprotein receptor class A domain-containing protein 4 (Ldlrad4) in the liver of rats treated with nongenotoxic hepatocarcinogen to induce transforming growth factor β signaling promoting cell proliferation and suppressing apoptosis in early hepatocarcinogenesis.
Ito Y, Nakajima K, Masubuchi Y, Kikuchi S, Okano H, Saito F, Akahori Y, Jin M, Yoshida T, Shibutani M. Ito Y, et al. Among authors: okano h. J Appl Toxicol. 2020 Nov;40(11):1467-1479. doi: 10.1002/jat.3998. Epub 2020 Jun 28. J Appl Toxicol. 2020. PMID: 32596862
Continuous exposure to α-glycosyl isoquercitrin from developmental stages to adulthood is necessary for facilitating fear extinction learning in rats.
Masubuchi Y, Nakahara J, Kikuchi S, Okano H, Takahashi Y, Takashima K, Koyanagi M, Maronpot RR, Yoshida T, Hayashi SM, Shibutani M. Masubuchi Y, et al. Among authors: okano h. J Toxicol Pathol. 2020 Oct;33(4):247-263. doi: 10.1293/tox.2020-0025. Epub 2020 Aug 13. J Toxicol Pathol. 2020. PMID: 33239843 Free PMC article.
A 28-day repeated oral dose toxicity study of enniatin complex in mice.
Okano H, Okamura T, Takahashi Y, Takashima K, Ojiro R, Tang Q, Jin M, Kikuchi S, Ogawa B, Yoshida T, Yoshinari T, Shibutani M. Okano H, et al. J Toxicol Sci. 2021;46(4):157-165. doi: 10.2131/jts.46.157. J Toxicol Sci. 2021. PMID: 33814509 Free article.
Induction of cellular senescence as a late effect and BDNF-TrkB signaling-mediated ameliorating effect on disruption of hippocampal neurogenesis after developmental exposure to lead acetate in rats.
Yamashita R, Takahashi Y, Takashima K, Okano H, Ojiro R, Tang Q, Kikuchi S, Kobayashi M, Ogawa B, Jin M, Kubota R, Ikarashi Y, Yoshida T, Shibutani M. Yamashita R, et al. Among authors: okano h. Toxicology. 2021 May 30;456:152782. doi: 10.1016/j.tox.2021.152782. Epub 2021 Apr 20. Toxicology. 2021. PMID: 33862172 Free article.
Disruption of postnatal neurogenesis and adult-stage suppression of synaptic plasticity in the hippocampal dentate gyrus after developmental exposure to sterigmatocystin in rats.
Takashima K, Nakajima K, Shimizu S, Ojiro R, Tang Q, Okano H, Takahashi Y, Ozawa S, Jin M, Yoshinari T, Yoshida T, Sugita-Konishi Y, Shibutani M. Takashima K, et al. Among authors: okano h. Toxicol Lett. 2021 Oct 1;349:69-83. doi: 10.1016/j.toxlet.2021.06.006. Epub 2021 Jun 11. Toxicol Lett. 2021. PMID: 34126181 Free article.
Aberrant neurogenesis and late onset suppression of synaptic plasticity as well as sustained neuroinflammation in the hippocampal dentate gyrus after developmental exposure to ethanol in rats.
Takahashi Y, Yamashita R, Okano H, Takashima K, Ogawa B, Ojiro R, Tang Q, Ozawa S, Woo GH, Yoshida T, Shibutani M. Takahashi Y, et al. Among authors: okano h. Toxicology. 2021 Oct;462:152958. doi: 10.1016/j.tox.2021.152958. Epub 2021 Sep 20. Toxicology. 2021. PMID: 34547370
1,671 results