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Highly Potent and Selective Dopamine D4 Receptor Antagonists Potentially Useful for the Treatment of Glioblastoma.
Pavletić P, Semeano A, Yano H, Bonifazi A, Giorgioni G, Piergentili A, Quaglia W, Sabbieti MG, Agas D, Santoni G, Pallini R, Ricci-Vitiani L, Sabato E, Vistoli G, Del Bello F. Pavletić P, et al. Among authors: yano h. J Med Chem. 2022 Sep 22;65(18):12124-12139. doi: 10.1021/acs.jmedchem.2c00840. Epub 2022 Sep 13. J Med Chem. 2022. PMID: 36098685 Free PMC article.
Synthesis and biological evaluation of a novel series of heterobivalent muscarinic ligands based on xanomeline and 1-[3-(4-butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1).
Bonifazi A, Yano H, Del Bello F, Farande A, Quaglia W, Petrelli R, Matucci R, Nesi M, Vistoli G, Ferré S, Piergentili A. Bonifazi A, et al. Among authors: yano h. J Med Chem. 2014 Nov 13;57(21):9065-77. doi: 10.1021/jm501173q. Epub 2014 Oct 16. J Med Chem. 2014. PMID: 25275964
Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.
Cao J, Slack RD, Bakare OM, Burzynski C, Rais R, Slusher BS, Kopajtic T, Bonifazi A, Ellenberger MP, Yano H, He Y, Bi GH, Xi ZX, Loland CJ, Newman AH. Cao J, et al. Among authors: yano h. J Med Chem. 2016 Dec 8;59(23):10676-10691. doi: 10.1021/acs.jmedchem.6b01373. Epub 2016 Nov 28. J Med Chem. 2016. PMID: 27933960 Free PMC article.
Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor.
Michino M, Boateng CA, Donthamsetti P, Yano H, Bakare OM, Bonifazi A, Ellenberger MP, Keck TM, Kumar V, Zhu C, Verma R, Deschamps JR, Javitch JA, Newman AH, Shi L. Michino M, et al. Among authors: yano h. J Med Chem. 2017 Jan 26;60(2):580-593. doi: 10.1021/acs.jmedchem.6b01148. Epub 2017 Jan 5. J Med Chem. 2017. PMID: 27983845 Free PMC article.
1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D4 Receptor.
Del Bello F, Bonifazi A, Giorgioni G, Cifani C, Micioni Di Bonaventura MV, Petrelli R, Piergentili A, Fontana S, Mammoli V, Yano H, Matucci R, Vistoli G, Quaglia W. Del Bello F, et al. Among authors: yano h. J Med Chem. 2018 Apr 26;61(8):3712-3725. doi: 10.1021/acs.jmedchem.8b00265. Epub 2018 Apr 6. J Med Chem. 2018. PMID: 29589445
Novel and Potent Dopamine D2 Receptor Go-Protein Biased Agonists.
Bonifazi A, Yano H, Guerrero AM, Kumar V, Hoffman AF, Lupica CR, Shi L, Newman AH. Bonifazi A, et al. Among authors: yano h. ACS Pharmacol Transl Sci. 2019 Feb 8;2(1):52-65. doi: 10.1021/acsptsci.8b00060. Epub 2019 Jan 14. ACS Pharmacol Transl Sci. 2019. PMID: 30775693 Free PMC article.
1,985 results