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Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer.
Salama R, Masson N, Simpson P, Sciesielski LK, Sun M, Tian YM, Ratcliffe PJ, Mole DR. Salama R, et al. Among authors: ratcliffe pj. PLoS One. 2015 Aug 11;10(8):e0134645. doi: 10.1371/journal.pone.0134645. eCollection 2015. PLoS One. 2015. PMID: 26262842 Free PMC article.
Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control.
Cheng X, Prange-Barczynska M, Fielding JW, Zhang M, Burrell AL, Lima JD, Eckardt L, Argles I, Pugh CW, Buckler KJ, Robbins PA, Hodson EJ, Bruick RK, Collinson LM, Rastinejad F, Bishop T, Ratcliffe PJ. Cheng X, et al. Among authors: ratcliffe pj. J Clin Invest. 2020 May 1;130(5):2237-2251. doi: 10.1172/JCI133194. J Clin Invest. 2020. PMID: 31999648 Free PMC article.
The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes.
Ortmann BM, Burrows N, Lobb IT, Arnaiz E, Wit N, Bailey PSJ, Jordon LH, Lombardi O, Peñalver A, McCaffrey J, Seear R, Mole DR, Ratcliffe PJ, Maxwell PH, Nathan JA. Ortmann BM, et al. Among authors: ratcliffe pj. Nat Genet. 2021 Jul;53(7):1022-1035. doi: 10.1038/s41588-021-00887-y. Epub 2021 Jun 21. Nat Genet. 2021. PMID: 34155378 Free PMC article.
Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma.
Eckardt L, Prange-Barczynska M, Hodson EJ, Fielding JW, Cheng X, Lima JDCC, Kurlekar S, Douglas G, Ratcliffe PJ, Bishop T. Eckardt L, et al. Among authors: ratcliffe pj. Endocr Relat Cancer. 2021 Oct 18;28(12):757-772. doi: 10.1530/ERC-21-0211. Endocr Relat Cancer. 2021. PMID: 34658364 Free PMC article.
Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6.
Cockman ME, Sugimoto Y, Pegg HB, Masson N, Salah E, Tumber A, Flynn HR, Kirkpatrick JM, Schofield CJ, Ratcliffe PJ. Cockman ME, et al. Among authors: ratcliffe pj. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2201483119. doi: 10.1073/pnas.2201483119. Epub 2022 Aug 5. Proc Natl Acad Sci U S A. 2022. PMID: 35930668 Free PMC article.
327 results