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Selective targeting of GARP-LTGFβ axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8+ T cell antitumor immunity.
Li A, Chang Y, Song NJ, Wu X, Chung D, Riesenberg BP, Velegraki M, Giuliani GD, Das K, Okimoto T, Kwon H, Chakravarthy KB, Bolyard C, Wang Y, He K, Gatti-Mays M, Das J, Yang Y, Gewirth DT, Ma Q, Carbone D, Li Z. Li A, et al. Among authors: li z. J Immunother Cancer. 2022 Sep;10(9):e005433. doi: 10.1136/jitc-2022-005433. J Immunother Cancer. 2022. PMID: 36096533 Free PMC article.
Characterization of the Grp94/OS-9 chaperone-lectin complex.
Seidler PM, Shinsky SA, Hong F, Li Z, Cosgrove MS, Gewirth DT. Seidler PM, et al. Among authors: li z. J Mol Biol. 2014 Oct 23;426(21):3590-605. doi: 10.1016/j.jmb.2014.08.024. Epub 2014 Sep 3. J Mol Biol. 2014. PMID: 25193139 Free PMC article.
Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.
Patel HJ, Patel PD, Ochiana SO, Yan P, Sun W, Patel MR, Shah SK, Tramentozzi E, Brooks J, Bolaender A, Shrestha L, Stephani R, Finotti P, Leifer C, Li Z, Gewirth DT, Taldone T, Chiosis G. Patel HJ, et al. Among authors: li z. J Med Chem. 2015 May 14;58(9):3922-43. doi: 10.1021/acs.jmedchem.5b00197. Epub 2015 Apr 22. J Med Chem. 2015. PMID: 25901531 Free PMC article.
Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94.
Ansa-Addo EA, Thaxton J, Hong F, Wu BX, Zhang Y, Fugle CW, Metelli A, Riesenberg B, Williams K, Gewirth DT, Chiosis G, Liu B, Li Z. Ansa-Addo EA, et al. Among authors: li z. Curr Top Med Chem. 2016;16(25):2765-78. doi: 10.2174/1568026616666160413141613. Curr Top Med Chem. 2016. PMID: 27072698 Free PMC article. Review.
Exploring the Functional Complementation between Grp94 and Hsp90.
Maharaj KA, Que NL, Hong F, Huck JD, Gill SK, Wu S, Li Z, Gewirth DT. Maharaj KA, et al. Among authors: li z. PLoS One. 2016 Nov 8;11(11):e0166271. doi: 10.1371/journal.pone.0166271. eCollection 2016. PLoS One. 2016. PMID: 27824935 Free PMC article.
Is CD47 an innate immune checkpoint for tumor evasion?
Liu X, Kwon H, Li Z, Fu YX. Liu X, et al. Among authors: li z. J Hematol Oncol. 2017 Jan 11;10(1):12. doi: 10.1186/s13045-016-0381-z. J Hematol Oncol. 2017. PMID: 28077173 Free PMC article. Review.
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