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Pharmacological activation of the C5a receptor leads to stimulation of the β-adrenergic receptor and alleviates cognitive impairment in a murine model of familial Alzheimer's disease.
Fella E, Papacharalambous R, Kynigopoulos D, Ioannou M, Derua R, Christodoulou C, Stylianou M, Karaiskos C, Kagiava A, Petroula G, Pierides C, Kyriakou M, Koumas L, Costeas P, Panayiotou E. Fella E, et al. Among authors: papacharalambous r. Front Immunol. 2022 Aug 26;13:947071. doi: 10.3389/fimmu.2022.947071. eCollection 2022. Front Immunol. 2022. PMID: 36091045 Free PMC article.
Genetic background modifies amyloidosis in a mouse model of ATTR neuropathy.
Panayiotou E, Papacharalambous R, Antoniou A, Christophides G, Papageorgiou L, Fella E, Malas S, Kyriakides T. Panayiotou E, et al. Among authors: papacharalambous r. Biochem Biophys Rep. 2016 Aug 11;8:48-54. doi: 10.1016/j.bbrep.2016.08.005. eCollection 2016 Dec. Biochem Biophys Rep. 2016. PMID: 28955941 Free PMC article.
A novel case of inclusion body myositis and myasthenia gravis.
Lambrianides S, Kinnis E, Cleanthous M, Papacharalambous R, Panayiotou E, Zamba-Papanicolaou E, Kyriakides T. Lambrianides S, et al. Among authors: papacharalambous r. Neuromuscul Disord. 2019 Oct;29(10):771-775. doi: 10.1016/j.nmd.2019.09.004. Epub 2019 Sep 6. Neuromuscul Disord. 2019. PMID: 31604651
C5aR agonist enhances phagocytosis of fibrillar and non-fibrillar Aβ amyloid and preserves memory in a mouse model of familial Alzheimer's disease.
Panayiotou E, Fella E, Andreou S, Papacharalambous R, Gerasimou P, Costeas P, Angeli S, Kousiappa I, Papacostas S, Kyriakides T. Panayiotou E, et al. Among authors: papacharalambous r. PLoS One. 2019 Dec 6;14(12):e0225417. doi: 10.1371/journal.pone.0225417. eCollection 2019. PLoS One. 2019. PMID: 31809505 Free PMC article.
Treatment of the CRND8 mouse model for cerebral amyloid angiopathy, exhibited increased levels of neuron specific enolase in brain tissue following long-term treatment with a modified C5a receptor agonist, accompanied by improved cognitive function.
Ioannou M, Fella E, Papacharalambous R, Kynigopoulos D, Panayiotou E. Ioannou M, et al. Among authors: papacharalambous r. Biochem Biophys Res Commun. 2023 Oct 1;675:78-84. doi: 10.1016/j.bbrc.2023.07.001. Epub 2023 Jul 5. Biochem Biophys Res Commun. 2023. PMID: 37454400 Free article.