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Pharmacological activation of the C5a receptor leads to stimulation of the β-adrenergic receptor and alleviates cognitive impairment in a murine model of familial Alzheimer's disease.
Fella E, Papacharalambous R, Kynigopoulos D, Ioannou M, Derua R, Christodoulou C, Stylianou M, Karaiskos C, Kagiava A, Petroula G, Pierides C, Kyriakou M, Koumas L, Costeas P, Panayiotou E. Fella E, et al. Front Immunol. 2022 Aug 26;13:947071. doi: 10.3389/fimmu.2022.947071. eCollection 2022. Front Immunol. 2022. PMID: 36091045 Free PMC article.
Genetic background modifies amyloidosis in a mouse model of ATTR neuropathy.
Panayiotou E, Papacharalambous R, Antoniou A, Christophides G, Papageorgiou L, Fella E, Malas S, Kyriakides T. Panayiotou E, et al. Among authors: fella e. Biochem Biophys Rep. 2016 Aug 11;8:48-54. doi: 10.1016/j.bbrep.2016.08.005. eCollection 2016 Dec. Biochem Biophys Rep. 2016. PMID: 28955941 Free PMC article.
C5aR agonist enhances phagocytosis of fibrillar and non-fibrillar Aβ amyloid and preserves memory in a mouse model of familial Alzheimer's disease.
Panayiotou E, Fella E, Andreou S, Papacharalambous R, Gerasimou P, Costeas P, Angeli S, Kousiappa I, Papacostas S, Kyriakides T. Panayiotou E, et al. Among authors: fella e. PLoS One. 2019 Dec 6;14(12):e0225417. doi: 10.1371/journal.pone.0225417. eCollection 2019. PLoS One. 2019. PMID: 31809505 Free PMC article.
Omega-3 fatty acids promote neuroprotection, decreased apoptosis and reduced glial cell activation in the retina of a mouse model of OPA1-related autosomal dominant optic atrophy.
Kalogerou M, Ioannou S, Kolovos P, Prokopiou E, Potamiti L, Kyriacou K, Panagiotidis M, Ioannou M, Fella E, Worth EP, Georgiou T. Kalogerou M, et al. Among authors: fella e. Exp Eye Res. 2022 Feb;215:108901. doi: 10.1016/j.exer.2021.108901. Epub 2021 Dec 20. Exp Eye Res. 2022. PMID: 34933001 Free article.
Treatment of the CRND8 mouse model for cerebral amyloid angiopathy, exhibited increased levels of neuron specific enolase in brain tissue following long-term treatment with a modified C5a receptor agonist, accompanied by improved cognitive function.
Ioannou M, Fella E, Papacharalambous R, Kynigopoulos D, Panayiotou E. Ioannou M, et al. Among authors: fella e. Biochem Biophys Res Commun. 2023 Oct 1;675:78-84. doi: 10.1016/j.bbrc.2023.07.001. Epub 2023 Jul 5. Biochem Biophys Res Commun. 2023. PMID: 37454400 Free article.