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Chemoproteomics-Enabled Identification of 4-Oxo-β-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9.
Carvalho LAR, Ross B, Fehr L, Bolgi O, Wöhrle S, Lum KM, Podlesainski D, Vieira AC, Kiefersauer R, Félix R, Rodrigues T, Lucas SD, Groß O, Geiss-Friedlander R, Cravatt BF, Huber R, Kaiser M, Moreira R. Carvalho LAR, et al. Among authors: kaiser m. Angew Chem Int Ed Engl. 2022 Nov 21;61(47):e202210498. doi: 10.1002/anie.202210498. Epub 2022 Oct 28. Angew Chem Int Ed Engl. 2022. PMID: 36089535 Free PMC article.
Binding mode of TMC-95A analogues to eukaryotic 20S proteasome.
Kaiser M, Groll M, Siciliano C, Assfalg-Machleidt I, Weyher E, Kohno J, Milbradt AG, Renner C, Huber R, Moroder L. Kaiser M, et al. Chembiochem. 2004 Sep 6;5(9):1256-66. doi: 10.1002/cbic.200400096. Chembiochem. 2004. PMID: 15368577
Conversion of a regulatory into a degradative protease.
Hasenbein S, Meltzer M, Hauske P, Kaiser M, Huber R, Clausen T, Ehrmann M. Hasenbein S, et al. Among authors: kaiser m. J Mol Biol. 2010 Apr 9;397(4):957-66. doi: 10.1016/j.jmb.2010.02.027. Epub 2010 Feb 22. J Mol Biol. 2010. PMID: 20184896
Protein quality control in the bacterial periplasm.
Merdanovic M, Clausen T, Kaiser M, Huber R, Ehrmann M. Merdanovic M, et al. Among authors: kaiser m. Annu Rev Microbiol. 2011;65:149-68. doi: 10.1146/annurev-micro-090110-102925. Annu Rev Microbiol. 2011. PMID: 21639788 Review.
Activation by substoichiometric inhibition.
Merdanovic M, Burston SG, Schmitz AL, Köcher S, Knapp S, Clausen T, Kaiser M, Huber R, Ehrmann M. Merdanovic M, et al. Among authors: kaiser m. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1414-1418. doi: 10.1073/pnas.1918721117. Epub 2020 Jan 6. Proc Natl Acad Sci U S A. 2020. PMID: 31907318 Free PMC article.
BacPROTACs mediate targeted protein degradation in bacteria.
Morreale FE, Kleine S, Leodolter J, Junker S, Hoi DM, Ovchinnikov S, Okun A, Kley J, Kurzbauer R, Junk L, Guha S, Podlesainski D, Kazmaier U, Boehmelt G, Weinstabl H, Rumpel K, Schmiedel VM, Hartl M, Haselbach D, Meinhart A, Kaiser M, Clausen T. Morreale FE, et al. Among authors: kaiser m. Cell. 2022 Jun 23;185(13):2338-2353.e18. doi: 10.1016/j.cell.2022.05.009. Epub 2022 Jun 3. Cell. 2022. PMID: 35662409 Free PMC article.
2,076 results