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Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells.
Takata F, Dohgu S, Matsumoto J, Machida T, Kaneshima S, Matsuo M, Sakaguchi S, Takeshige Y, Yamauchi A, Kataoka Y. Takata F, et al. Among authors: yamauchi a. Biochem Biophys Res Commun. 2013 Apr 19;433(4):586-90. doi: 10.1016/j.bbrc.2013.03.036. Epub 2013 Mar 21. Biochem Biophys Res Commun. 2013. PMID: 23523792
Varenicline aggravates atherosclerotic plaque formation in nicotine-pretreated ApoE knockout mice due to enhanced oxLDL uptake by macrophages through downregulation of ABCA1 and ABCG1 expression.
Koga M, Kanaoka Y, Okamoto M, Nakao Y, Inada K, Takayama S, Kataoka Y, Yamauchi A. Koga M, et al. Among authors: yamauchi a. J Pharmacol Sci. 2020 Jan;142(1):9-15. doi: 10.1016/j.jphs.2019.11.002. Epub 2019 Nov 14. J Pharmacol Sci. 2020. PMID: 31771811 Free article.
Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro.
Takata F, Dohgu S, Matsumoto J, Takahashi H, Machida T, Wakigawa T, Harada E, Miyaji H, Koga M, Nishioku T, Yamauchi A, Kataoka Y. Takata F, et al. Among authors: yamauchi a. J Neuroinflammation. 2011 Aug 26;8:106. doi: 10.1186/1742-2094-8-106. J Neuroinflammation. 2011. PMID: 21867555 Free PMC article.
990 results