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A computational cardiopulmonary physiology simulator accurately predicts individual patient responses to changes in mechanical ventilator settings.
Mistry S, Brook BS, Saffaran S, Chikhani M, Hannon DM, Laffey JG, Scott TE, Camporota L, Hardman JG, Bates DG. Mistry S, et al. Among authors: brook bs. Annu Int Conf IEEE Eng Med Biol Soc. 2022 Jul;2022:3261-3264. doi: 10.1109/EMBC48229.2022.9871182. Annu Int Conf IEEE Eng Med Biol Soc. 2022. PMID: 36083938
Modeling Mechanical Ventilation In Silico-Potential and Pitfalls.
Hannon DM, Mistry S, Das A, Saffaran S, Laffey JG, Brook BS, Hardman JG, Bates DG. Hannon DM, et al. Among authors: brook bs. Semin Respir Crit Care Med. 2022 Jun;43(3):335-345. doi: 10.1055/s-0042-1744446. Epub 2022 Apr 21. Semin Respir Crit Care Med. 2022. PMID: 35451046 Review.
In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss.
Chernyavsky IL, Russell RJ, Saunders RM, Morris GE, Berair R, Singapuri A, Chachi L, Mansur AH, Howarth PH, Dennison P, Chaudhuri R, Bicknell S, Rose FRAJ, Siddiqui S, Brook BS, Brightling CE. Chernyavsky IL, et al. Among authors: brook bs. Eur Respir J. 2018 May 24;51(5):1701680. doi: 10.1183/13993003.01680-2017. Print 2018 May. Eur Respir J. 2018. PMID: 29700102 Free PMC article.
An Integrated Pipeline for Combining in vitro Data and Mathematical Models Using a Bayesian Parameter Inference Approach to Characterize Spatio-temporal Chemokine Gradient Formation.
Kalogiros DI, Russell MJ, Bonneuil WV, Frattolin J, Watson D, Moore JE Jr, Kypraios T, Brook BS. Kalogiros DI, et al. Among authors: brook bs. Front Immunol. 2019 Oct 11;10:1986. doi: 10.3389/fimmu.2019.01986. eCollection 2019. Front Immunol. 2019. PMID: 31681255 Free PMC article.
DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment.
Saunders R, Kaul H, Berair R, Gonem S, Singapuri A, Sutcliffe AJ, Chachi L, Biddle MS, Kaur D, Bourne M, Pavord ID, Wardlaw AJ, Siddiqui SH, Kay RA, Brook BS, Smallwood RH, Brightling CE. Saunders R, et al. Among authors: brook bs. Sci Transl Med. 2019 Feb 13;11(479):eaao6451. doi: 10.1126/scitranslmed.aao6451. Sci Transl Med. 2019. PMID: 30760581 Free article. Clinical Trial.
41 results