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Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's.
Toomey CE, Heywood WE, Evans JR, Lachica J, Pressey SN, Foti SC, Al Shahrani M, D'Sa K, Hargreaves IP, Heales S, Orford M, Troakes C, Attems J, Gelpi E, Palkovits M, Lashley T, Gentleman SM, Revesz T, Mills K, Gandhi S. Toomey CE, et al. Among authors: orford m. Acta Neuropathol Commun. 2022 Sep 8;10(1):134. doi: 10.1186/s40478-022-01424-6. Acta Neuropathol Commun. 2022. PMID: 36076304 Free PMC article.
K.Vita: a feasibility study of a blend of medium chain triglycerides to manage drug-resistant epilepsy.
Schoeler NE, Orford M, Vivekananda U, Simpson Z, Van de Bor B, Smith H, Balestrini S, Rutherford T, Brennan E, McKenna J, Lambert B, Barker T, Jackson R, Williams RSB, Sisodiya SM, Eaton S, Heales SJR, Cross JH, Walker MC; K.Vita Study Group. Schoeler NE, et al. Among authors: orford m. Brain Commun. 2021 Jul 23;3(4):fcab160. doi: 10.1093/braincomms/fcab160. eCollection 2021. Brain Commun. 2021. PMID: 34729477 Free PMC article.
Classic ketogenic diet versus further antiseizure medicine in infants with drug-resistant epilepsy (KIWE): a UK, multicentre, open-label, randomised clinical trial.
Schoeler NE, Marston L, Lyons L, Halsall S, Jain R, Titre-Johnson S, Balogun M, Heales SJR, Eaton S, Orford M, Neal E, Reilly C, Eltze C, Stephen E, Mallick AA, O'Callaghan F, Agrawal S, Parker A, Kirkpatrick M, Brunklaus A, McLellan A, McCullagh H, Samanta R, Kneen R, Tan HJ, Devlin A, Prasad M, Rattihalli R, Basu H, Desurkar A, Williams R, Fallon P, Nazareth I, Freemantle N, Cross JH; KIWE study group. Schoeler NE, et al. Among authors: orford m. Lancet Neurol. 2023 Dec;22(12):1113-1124. doi: 10.1016/S1474-4422(23)00370-8. Lancet Neurol. 2023. PMID: 37977712 Free article. Clinical Trial.
Ageing contributes to phenotype transition in a mouse model of periodic paralysis.
Suetterlin KJ, Tan SV, Mannikko R, Phadke R, Orford M, Eaton S, Sayer AA, Grounds MD, Matthews E, Greensmith L, Hanna MG. Suetterlin KJ, et al. Among authors: orford m. JCSM Rapid Commun. 2021 Jul-Dec;4(2):245-259. doi: 10.1002/rco2.41. Epub 2021 May 5. JCSM Rapid Commun. 2021. PMID: 35174322 Free PMC article.
Liposomal delivery of hydrophobic RAMBAs provides good bioavailability and significant enhancement of retinoic acid signalling in neuroblastoma tumour cells.
Bilip M, Shah S, Mathiyalakan M, Tagalakis AD, Hart SL, Maeshima R, Eaton S, Orford M, Irving E, Di Florio A, Simons C, Stoker AW. Bilip M, et al. Among authors: orford m. J Drug Target. 2020 Jul;28(6):643-654. doi: 10.1080/1061186X.2019.1710157. Epub 2020 Jan 14. J Drug Target. 2020. PMID: 31903789 Free PMC article.
Engineering transplantable jejunal mucosal grafts using patient-derived organoids from children with intestinal failure.
Meran L, Massie I, Campinoti S, Weston AE, Gaifulina R, Tullie L, Faull P, Orford M, Kucharska A, Baulies A, Novellasdemunt L, Angelis N, Hirst E, König J, Tedeschi AM, Pellegata AF, Eli S, Snijders AP, Collinson L, Thapar N, Thomas GMH, Eaton S, Bonfanti P, De Coppi P, Li VSW. Meran L, et al. Among authors: orford m. Nat Med. 2020 Oct;26(10):1593-1601. doi: 10.1038/s41591-020-1024-z. Epub 2020 Sep 7. Nat Med. 2020. PMID: 32895569 Free PMC article.
43 results