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Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicity.
iScience. 2022 Aug 17;25(9):104958. doi: 10.1016/j.isci.2022.104958. eCollection 2022 Sep 16.
iScience. 2022.
PMID: 36072551
Free PMC article.
A novel Carcinoembryonic Antigen (CEA)-Targeted Trimeric Immunotoxin shows significantly enhanced Antitumor Activity in Human Colorectal Cancer Xenografts.
Lázaro-Gorines R, Ruiz-de-la-Herrán J, Navarro R, Sanz L, Álvarez-Vallina L, Martínez-Del-Pozo A, Gavilanes JG, Lacadena J.
Lázaro-Gorines R, et al.
Sci Rep. 2019 Aug 12;9(1):11680. doi: 10.1038/s41598-019-48285-z.
Sci Rep. 2019.
PMID: 31406218
Free PMC article.
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A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response.
Rubio-Pérez L, Lázaro-Gorines R, Harwood SL, Compte M, Navarro R, Tapia-Galisteo A, Bonet J, Blanco B, Lykkemark S, Ramírez-Fernández Á, Ferreras-Gutiérrez M, Domínguez-Alonso C, Díez-Alonso L, Segura-Tudela A, Hangiu O, Erce-Llamazares A, Blanco FJ, Santos C, Rodríguez-Peralto JL, Sanz L, Álvarez-Vallina L.
Rubio-Pérez L, et al. Among authors: lazaro gorines r.
Oncoimmunology. 2023 Apr 24;12(1):2205336. doi: 10.1080/2162402X.2023.2205336. eCollection 2023.
Oncoimmunology. 2023.
PMID: 37114242
Free PMC article.
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Dendritic Cell-Mediated Cross-Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS-CoV-2.
Lázaro-Gorines R, Pérez P, Heras-Murillo I, Adán-Barrientos I, Albericio G, Astorgano D, Flores S, Luczkowiak J, Labiod N, Harwood SL, Segura-Tudela A, Rubio-Pérez L, Nugraha Y, Shang X, Li Y, Alfonso C, Adipietro KA, Abeyawardhane DL, Navarro R, Compte M, Yu W, MacKerell AD Jr, Sanz L, Weber DJ, Blanco FJ, Esteban M, Pozharski E, Godoy-Ruiz R, Muñoz IG, Delgado R, Sancho D, García-Arriaza J, Álvarez-Vallina L.
Lázaro-Gorines R, et al.
Adv Sci (Weinh). 2023 Dec;10(34):e2304818. doi: 10.1002/advs.202304818. Epub 2023 Oct 20.
Adv Sci (Weinh). 2023.
PMID: 37863812
Free PMC article.
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Fungal Ribotoxins: A Review of Potential Biotechnological Applications.
Olombrada M, Lázaro-Gorines R, López-Rodríguez JC, Martínez-Del-Pozo Á, Oñaderra M, Maestro-López M, Lacadena J, Gavilanes JG, García-Ortega L.
Olombrada M, et al. Among authors: lazaro gorines r.
Toxins (Basel). 2017 Feb 21;9(2):71. doi: 10.3390/toxins9020071.
Toxins (Basel). 2017.
PMID: 28230789
Free PMC article.
Review.
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Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin α-Sarcin- or RNase T1-Based Immunotoxins.
Ruiz-de-la-Herrán J, Tomé-Amat J, Lázaro-Gorines R, Gavilanes JG, Lacadena J.
Ruiz-de-la-Herrán J, et al. Among authors: lazaro gorines r.
Toxins (Basel). 2019 Oct 12;11(10):593. doi: 10.3390/toxins11100593.
Toxins (Basel). 2019.
PMID: 31614771
Free PMC article.
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Der p 1-based immunotoxin as potential tool for the treatment of dust mite respiratory allergy.
Lázaro-Gorines R, López-Rodríguez JC, Benedé S, González M, Mayorga C, Vogel L, Martínez-Del-Pozo Á, Lacadena J, Villalba M.
Lázaro-Gorines R, et al.
Sci Rep. 2020 Jul 23;10(1):12255. doi: 10.1038/s41598-020-69166-w.
Sci Rep. 2020.
PMID: 32703972
Free PMC article.
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Pharmacokinetics and safety of LEAD-452, an EGFR-specific 4-1BB-agonistic trimerbody in non-human primates.
Navarro R, Frago S, Hangiu O, Erce-Llamazares A, Lázaro-Gorines R, Morcillo MA, Rodriguez-Peralto JL, Sanz L, Compte M, Alvarez-Vallina L.
Navarro R, et al. Among authors: lazaro gorines r.
Toxicol Appl Pharmacol. 2024 May 11;487:116961. doi: 10.1016/j.taap.2024.116961. Online ahead of print.
Toxicol Appl Pharmacol. 2024.
PMID: 38740095
Free article.
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